Department of Otolaryngology - Head and Neck Surgery, The University of Ottawa, Ottawa, Canada.
The Ottawa Hospital Research Institute (OHRI), Ottawa, Canada.
Rhinology. 2018 Jun 1;56(2):155-157. doi: 10.4193/Rhin17.115.
Endoscopic Polypectomy In Clinic (EPIC) is a recently described deescalated form of endoscopic sinus surgery (ESS) performed in the outpatient clinic for patients with chronic rhinosinusitis with polyps (CRSwNP). The quality of life benefit of EPIC in comparison to ESS is not known. The purpose of this study was to determine if the disease specific quality of life measured with the SNOT-22 attained with EPIC is similar to that attained with ESS for patients with CRSwNP.
A multi-institutional observational case-control study was performed to evaluate quality of life improvement in patients treated with ESS and EPIC for CRSwNP with a 3 month follow-up. Predicted probability of undergoing EPIC was calculated by fitting a logistic regression model using clinically relevant variables. EPIC patients were matched to ESS patients in a 1:1 fashion.
24 pairs were analyzed after matching. There was no statistical difference in the post-treatment SNOT-22 scores or proportion of patients achieving a minimal clinically important difference.
In appropriate CRSwNP patients, the EPIC procedure may provide disease specific quality of life improvement similar to that seen with patients who undergo traditional ESS.
内镜下息肉切除术（EPIC）是一种最近描述的内镜鼻窦手术（ESS）降级形式，在门诊为慢性鼻-鼻窦炎伴息肉（CRSwNP）患者进行。EPIC 与 ESS 相比的生活质量获益尚不清楚。本研究旨在确定使用 SNOT-22 测量的 EPIC 治疗 CRSwNP 患者的疾病特异性生活质量是否与 ESS 治疗的患者相似。
进行了一项多机构观察性病例对照研究，以评估 ESS 和 EPIC 治疗 CRSwNP 患者的 3 个月随访时的生活质量改善情况。使用临床相关变量拟合逻辑回归模型来计算接受 EPIC 的预测概率。以 1:1 的比例将 EPIC 患者与 ESS 患者相匹配。
匹配后分析了 24 对。治疗后 SNOT-22 评分或达到最小临床重要差异的患者比例没有统计学差异。
在适当的 CRSwNP 患者中，EPIC 手术可能会提供与接受传统 ESS 治疗的患者相似的疾病特异性生活质量改善。
