角膜移植中诱导免疫耐受和免疫静止的治疗方法。
Therapeutic approaches for induction of tolerance and immune quiescence in corneal allotransplantation.
机构信息
Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
Kresge Eye Institute, Wayne State University, Detroit, MI, USA.
出版信息
Cell Mol Life Sci. 2018 May;75(9):1509-1520. doi: 10.1007/s00018-017-2739-y. Epub 2018 Jan 6.
Abstract
The cornea is the most commonly transplanted tissue in the body. Corneal grafts in low-risk recipients enjoy high success rates, yet over 50% of high-risk grafts (with inflamed and vascularized host beds) are rejected. As our understanding of the cellular and molecular pathways that mediate rejection has deepened, a number of novel therapeutic strategies have been unveiled. This manuscript reviews therapeutic approaches to promote corneal transplant survival through targeting (1) corneal lymphangiogenesis and hemangiogenesis, (2) antigen presenting cells, (3) effector and regulatory T cells, and (4) mesenchymal stem cells.
摘要
角膜是人体最常移植的组织。在低危受者中，角膜移植物成功率很高，但超过 50%的高危移植物（伴有炎症和血管化宿主床）被排斥。随着我们对介导排斥反应的细胞和分子途径的理解加深，已经揭示了许多新的治疗策略。本文综述了通过靶向（1）角膜淋巴管生成和血管生成，（2）抗原呈递细胞，（3）效应和调节 T 细胞，以及（4）间充质干细胞，来促进角膜移植存活的治疗方法。
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本文引用的文献
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Curr Opin Organ Transplant. 2016 Dec;21(6):559-567. doi: 10.1097/MOT.0000000000000360.
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