Suppr超能文献

IVAG:基于R-Shiny和Docker平台的用于各类基因组数据的集成可视化应用程序。

IVAG: An Integrative Visualization Application for Various Types of Genomic Data Based on R-Shiny and the Docker Platform.

作者信息

Lee Tae-Rim, Ahn Jin Mo, Kim Gyuhee, Kim Sangsoo

机构信息

Department of Bioinformatics and Life Science, Soongsil University, Seoul 06978, Korea.

出版信息

Genomics Inform. 2017 Dec;15(4):178-182. doi: 10.5808/GI.2017.15.4.178. Epub 2017 Dec 29.

Abstract

Next-generation sequencing (NGS) technology has become a trend in the genomics research area. There are many software programs and automated pipelines to analyze NGS data, which can ease the pain for traditional scientists who are not familiar with computer programming. However, downstream analyses, such as finding differentially expressed genes or visualizing linkage disequilibrium maps and genome-wide association study (GWAS) data, still remain a challenge. Here, we introduce a dockerized web application written in R using the Shiny platform to visualize pre-analyzed RNA sequencing and GWAS data. In addition, we have integrated a genome browser based on the JBrowse platform and an automated intermediate parsing process required for custom track construction, so that users can easily build and navigate their personal genome tracks with in-house datasets. This application will help scientists perform series of downstream analyses and obtain a more integrative understanding about various types of genomic data by interactively visualizing them with customizable options.

摘要

下一代测序(NGS)技术已成为基因组学研究领域的一种趋势。有许多软件程序和自动化流程来分析NGS数据,这可以减轻不熟悉计算机编程的传统科学家的负担。然而,下游分析,如寻找差异表达基因或可视化连锁不平衡图谱以及全基因组关联研究(GWAS)数据,仍然是一项挑战。在这里,我们介绍一个使用Shiny平台用R编写的容器化Web应用程序,以可视化预先分析的RNA测序和GWAS数据。此外,我们集成了基于JBrowse平台的基因组浏览器和自定义轨迹构建所需的自动化中间解析过程,以便用户可以使用内部数据集轻松构建和浏览个人基因组轨迹。该应用程序将帮助科学家进行一系列下游分析,并通过使用可定制选项交互式地可视化各种类型的基因组数据,从而对它们有更全面的了解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed7b/5769861/df981d45be10/gi-15-4-178f1.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验