Iwagaki Yui, Sugawara Saeko, Huruya Yasuhisa, Sato Miki, Wu Qiming, E Shuang, Yamamoto Kazushi, Tsuduki Tsuyoshi
a Laboratory of Food and Biomolecular Science, Graduate School of Agriculture , Tohoku University , Sendai , Japan.
Biosci Biotechnol Biochem. 2018 Apr;82(4):709-715. doi: 10.1080/09168451.2017.1417022. Epub 2018 Jan 8.
We aimed to find new physiological effects of the Japanese diet. First, to determine the key components in serum from mice fed the 1975 diet, serum from mice fed the 1960, 1975, 1990 or 2005 Japanese diet was analyzed using CE-TOFMS and LC-TOFMS. Based on these results, the key components were determined by principal component analysis. Among the identified compounds, GABA was included. Therefore, a stress reduction effect was inferred as a novel physiological effect of this diet. Next, we tested whether the 1975 diet had an actual stress reduction effect in mice. Mice were given the 1975 diet or a control diet for 4 weeks, after which they were divided into restraint stress and non-stress groups. Mice fed the 1975 diet had significantly decreased stress parameters compared with those fed the control diet. These results provide the first evidence that the 1975 Japanese diet has a stress reduction effect.
我们旨在探寻日本饮食的新生理效应。首先，为确定喂食1975年饮食的小鼠血清中的关键成分，我们使用毛细管电泳飞行时间质谱仪（CE - TOFMS）和液相色谱飞行时间质谱仪（LC - TOFMS）对喂食1960年、1975年、1990年或2005年日本饮食的小鼠血清进行了分析。基于这些结果，通过主成分分析确定了关键成分。在鉴定出的化合物中，包含γ-氨基丁酸（GABA）。因此，推断出减压效应是这种饮食的一种新生理效应。接下来，我们测试了1975年饮食对小鼠是否具有实际的减压效果。给小鼠喂食1975年饮食或对照饮食4周，之后将它们分为束缚应激组和非应激组。与喂食对照饮食的小鼠相比，喂食1975年饮食的小鼠应激参数显著降低。这些结果首次证明1975年的日本饮食具有减压作用。
