新型M-V-O衍生物对黄嘌呤氧化酶的体外作用
In vitro effects of novel type M-V-O derivatives on Xanthine Oxidase.
作者信息
Kaya Mustafa Oğuzhan, Gül Gülşah Çeli K, Kurtuluş Figen
机构信息
Faculty of Veterinary Medicine, Division of Basic Sciences, Biochemistry Department, Siirt University, Siirt, Turkey.
Faculty of Arts and Sciences, Department of Chemistry/Inorganic Chemistry Section, BalikesirUniversity, Balikesir Turkey.
出版信息
Cell Mol Biol (Noisy-le-grand). 2017 Dec 30;63(12):25-28. doi: 10.14715/cmb/2017.63.12.7.
Xanthine Oxidase (XO) is related with different diseases such as vascular, gout, nephropathy and renal stone diseases that are relevant to high uric acid levels and oxidative stress. Some common natural inhibitors of xanthine oxidase are known as rosmarinic acid and apigenin. With this study, we aimed to determine inhibitory effects of originally synthesized new generation transition metal vanadates on Xanthine Oxidase (XO) from bovine milk. Because, Xanthine oxidase inhibitors are typically used in the treatment of gout and nephropathy and renal stone diseases linked to hyperuricaemia. We found considerable IC50 constants for inhibition of XO. Among the synthesized compounds, Cu‒V‒O was found to be the most active (IC50 = 7.119 mM) for inhibition of XO.
黄嘌呤氧化酶（XO）与多种疾病相关，如血管疾病、痛风、肾病和肾结石疾病，这些疾病都与高尿酸水平和氧化应激有关。一些常见的黄嘌呤氧化酶天然抑制剂包括迷迭香酸和芹菜素。在本研究中，我们旨在确定新合成的新一代过渡金属钒酸盐对牛乳中黄嘌呤氧化酶（XO）的抑制作用。因为，黄嘌呤氧化酶抑制剂通常用于治疗与高尿酸血症相关的痛风、肾病和肾结石疾病。我们发现了抑制XO的相当可观的IC50常数。在合成的化合物中，发现Cu‒V‒O对XO的抑制作用最活跃（IC50 = 7.119 mM）。
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