BRCA 突变与生殖。
BRCA mutations and reproduction.
机构信息
Department of Genetic and Metabolic Diseases, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Sharett Oncology Institute, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
出版信息
Fertil Steril. 2018 Jan;109(1):33-38. doi: 10.1016/j.fertnstert.2017.12.004.
Deleterious mutations in BRCA1 or BRCA2 genes have long been recognized as independent risk factors, mostly for breast and ovarian cancer. Numerous studies have evaluated the molecular processes involving these genes, the pathophysiology of BRCAness, follow up options and modes of prophylaxis. The fertility of BRCA carriers, however, has not been widely investigated. The aim of the present work is to review the literature pertaining to this issue.
BRCA1 或 BRCA2 基因中的有害突变长期以来一直被认为是独立的风险因素，主要与乳腺癌和卵巢癌有关。许多研究评估了涉及这些基因的分子过程、BRCA 相关性的病理生理学、随访选择和预防模式。然而，BRCA 携带者的生育能力尚未得到广泛研究。本研究旨在综述相关文献。
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