International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai, 200438, China.
International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai, 200438, China; National Center for Liver Cancer Research, Shanghai, 201805, China.
Cancer Lett. 2018 Apr 1;418:51-63. doi: 10.1016/j.canlet.2018.01.001. Epub 2018 Jan 4.
The high rate of recurrence and heterogeneity make hepatocellular carcinoma (HCC) as one of the most prevalent malignancy worldwide. Cancer stem cells (CSCs), also known as tumor-initiating cells, are responsible for cancer initiation, metastasis, drug resistance and relapse, accounting for the heterogeneous and hierarchical organizations of HCC. Therefore, CSCs are novel targets for more efficient liver cancer therapies. New data continues to mount on the functions of noncoding RNAs in multiple processes of liver CSCs, including malignant proliferation, self-renewal, tumorigenicity, and survival. Thus, it is highly critical to develop improved understanding of the mechanisms by which noncoding RNAs control CSCs functions for developing better diagnostic and therapeutic strategies. Herein, we will shed light on the regulatory roles of noncoding RNAs, especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), in liver CSCs acquisition and maintenance after presenting an overview about the characteristics of liver CSCs and their origins.
肝癌（HCC）的高复发率和异质性使其成为全球最常见的恶性肿瘤之一。癌症干细胞（CSC），也称为肿瘤起始细胞，负责癌症的发生、转移、耐药和复发，是 HCC 异质性和层次结构的基础。因此，CSC 是更有效肝癌治疗的新靶点。越来越多的新数据表明，非编码 RNA 在肝 CSC 的多个过程中发挥作用，包括恶性增殖、自我更新、致瘤性和存活。因此，深入了解非编码 RNA 控制 CSC 功能的机制对于开发更好的诊断和治疗策略至关重要。本文将重点介绍非编码 RNA，特别是 microRNAs（miRNAs）和长非编码 RNA（lncRNAs），在肝 CSC 获得和维持中的调控作用，并概述肝 CSC 的特征及其起源。
