Cai Zhaobin, Xu Keyang, Li Yan, Lv Yuanlin, Bao Jianfeng, Qiao Liang
The Hangzhou Xixi Hospital Affiliated to the Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310023, China.
These authors contributed equally to this article.
Discov Med. 2017 Sep;24(131):87-93.
Hepatocellular carcinoma (HCC) is one of the most common malignancies and a major cause of cancer-related deaths. HCC often has an insidious onset, fast progression, and high tendency of metastasis and recurrence, hence it is a highly fatal malignant tumor. The origin of HCC is still a topic of debate but studies over the past decade have clearly identified liver cancer stem cells (LCSCs) being a cardinal source of liver cancer. LCSCs are a small subset of cells with the unlimited ability of self-renewal, differentiation, and uncontrollable growth. LCSCs are also resistant to conventional therapies and are thus believed to be responsible for treatment failure. Recent studies have indicated that long noncoding RNA (lncRNAs) may play important roles in the regulation of the biological functions of cancer stem cells (CSCs). The roles of lncRNAs on the biological properties of LCSCs are unknown. In this review, we briefly summarize the published studies on the functions and underlying mechanisms of commonly reported lncRNAs in the regulation of LCSCs.
肝细胞癌（HCC）是最常见的恶性肿瘤之一，也是癌症相关死亡的主要原因。HCC通常起病隐匿，进展迅速，转移和复发倾向高，因此是一种高度致命的恶性肿瘤。HCC的起源仍是一个有争议的话题，但过去十年的研究已明确确定肝癌干细胞（LCSCs）是肝癌的主要来源。LCSCs是一小部分具有无限自我更新、分化和不可控生长能力的细胞。LCSCs对传统疗法也具有抗性，因此被认为是治疗失败的原因。最近的研究表明，长链非编码RNA（lncRNAs）可能在癌症干细胞（CSCs）生物学功能的调节中发挥重要作用。lncRNAs对LCSCs生物学特性的作用尚不清楚。在本综述中，我们简要总结了已发表的关于常见lncRNAs在调节LCSCs中的功能和潜在机制的研究。
