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以双侧间质性肺炎为表现的急性人类免疫缺陷病毒（HIV）感染：病例报告及对潜在HIV诱导的间质性肺炎的讨论

Acute Human Immunodeficiency Virus (HIV) Infection Presenting With Bilateral Interstitial Pneumonia: Case Report and Discussion of Potential HIV-Induced Interstitial Pneumonia.

作者信息

Peri Anna Maria, Alagna Laura, Trovati Serena, Sabbatini Francesca, Rona Roberto, Simonetti Francesco Roberto, Foresti Sergio, Migliorino Guglielmo Marco, Gori Andrea, Bandera Alessandra

机构信息

Division of Infectious Diseases, San Gerardo Hospital, Monza, Italy.

Intensive Care Unit, San Gerardo Hospital, Monza, Italy.

出版信息

Open Forum Infect Dis. 2017 Nov 20;4(4):ofx256. doi: 10.1093/ofid/ofx256. eCollection 2017 Fall.

DOI:10.1093/ofid/ofx256
PMID:29308407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5751086/
Abstract

A 50-year-old man was admitted to intensive care unit because of acute respiratory failure due interstitial pneumonia; after admission, a diagnosis of acute human immunodeficiency virus (HIV)-1 infection was made. Clinical and radiological improvement was observed only after introduction of antiretroviral treatment. We discuss the hypothesis of interstitial pneumonia induced by the acute HIV-1 infection.

摘要

一名50岁男性因间质性肺炎导致急性呼吸衰竭入住重症监护病房；入院后，确诊为急性人类免疫缺陷病毒1型（HIV-1）感染。仅在开始抗逆转录病毒治疗后，临床和影像学表现才有所改善。我们讨论了急性HIV-1感染诱发间质性肺炎的假说。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79f/5751086/bca3d32274fb/ofx25601.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79f/5751086/bca3d32274fb/ofx25601.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b79f/5751086/bca3d32274fb/ofx25601.jpg

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本文引用的文献

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HIV Reprograms Human Airway Basal Stem/Progenitor Cells to Acquire a Tissue-Destructive Phenotype.人类免疫缺陷病毒使气道基底干细胞/祖细胞发生重编程，进而获得组织破坏性表型。
Cell Rep. 2017 May 9;19(6):1091-1100. doi: 10.1016/j.celrep.2017.04.026.
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Frequency and Spectrum of Unexpected Clinical Manifestations of Primary HIV-1 Infection.原发性 HIV-1 感染的意外临床表现的频率和频谱。
Clin Infect Dis. 2015 Sep 15;61(6):1013-21. doi: 10.1093/cid/civ398. Epub 2015 May 19.
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Healthy HIV-1-infected individuals on highly active antiretroviral therapy harbor HIV-1 in their alveolar macrophages.
接受高效抗逆转录病毒治疗的健康HIV-1感染者，其肺泡巨噬细胞中存有HIV-1。
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4
The complexity of HIV persistence and pathogenesis in the lung under antiretroviral therapy: challenges beyond AIDS.抗逆转录病毒治疗下肺部HIV持续存在和发病机制的复杂性：超越艾滋病的挑战。
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Impact of antiretroviral therapy on lung immunology and inflammation.抗反转录病毒疗法对肺部免疫和炎症的影响。
Clin Chest Med. 2013 Jun;34(2):155-64. doi: 10.1016/j.ccm.2013.01.004. Epub 2013 Apr 8.
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Acute human immunodeficiency virus infection.急性人类免疫缺陷病毒感染。
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J Virol. 2012 Jun;86(12):6835-46. doi: 10.1128/JVI.00437-12. Epub 2012 Apr 18.
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HIV infection and risk for incident pulmonary diseases in the combination antiretroviral therapy era.在联合抗逆转录病毒治疗时代，HIV 感染与新发肺部疾病的风险。
Am J Respir Crit Care Med. 2011 Feb 1;183(3):388-95. doi: 10.1164/rccm.201006-0836OC. Epub 2010 Sep 17.
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Acute HIV infection with rapid progression to AIDS.急性 HIV 感染，迅速进展至艾滋病。
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