Ben-Rafael Z, Carp H J, Mashiach S, Blankstein J, Serr D M
Acta Eur Fertil. 1985 May-Jun;16(3):199-202.
Concurrent intra and extrauterine pregnancies have always been thought to be rare with a mean annual incidence of 1:30.000. The condition has been reported more frequently in the recent literature. If the incidence is increasing it is a serious development as the condition is often undiagnosed. The paper describes 5 patients with the condition presenting between 1976-1981 an incidence of 1:4000 deliveries. In two of these five patients the intrauterine pregnancy was diagnosed first and the ectopic pregnancy was undiagnosed until much later. The presence of intrauterine pregnancy often leads us to ignore the possibility of a concurrent extrauterine pregnancy. Considering that ectopic pregnancy may still cause maternal death, we believe that the condition has to be considered more often. Certain features may suggest the diagnosis. 1) Lack of vaginal bleeding or uterus larger than 9 week size with a proven ectopic pregnancy. 2) Presence of two corpora lutea at laparoscopy. 3) Ultrasound to diagnose an adnexal mass. 4) Failure of serum hCG to return to normal after abortion. The text also discusses the natural history of the condition and the higher incidence expected in the future with the wider use of ovulation inducing agents.
同时合并宫内和宫外妊娠一直被认为很罕见,年平均发病率为1:30000。近期文献中对这种情况的报道更为频繁。如果发病率在上升,这是一个严重的情况,因为这种情况往往未被诊断出来。本文描述了1976年至1981年间出现这种情况的5例患者,发病率为1:4000次分娩。在这5例患者中的2例中,首先诊断出宫内妊娠,而异位妊娠直到很久以后才被诊断出来。宫内妊娠的存在常常使我们忽视同时合并宫外妊娠的可能性。鉴于异位妊娠仍可能导致孕产妇死亡,我们认为必须更频繁地考虑这种情况。某些特征可能提示诊断。1) 有异位妊娠但无阴道出血或子宫大于9周大小。2) 腹腔镜检查时发现两个黄体。3) 超声诊断附件包块。4) 流产后血清人绒毛膜促性腺激素未能恢复正常。本文还讨论了这种情况的自然病程以及随着促排卵药物的更广泛使用未来预期的更高发病率。