Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
J Affect Disord. 2018 Mar 15;229:141-144. doi: 10.1016/j.jad.2017.12.069. Epub 2018 Jan 3.
Since postpartum psychosis has been linked to activation of the immune system, it has been hypothesized that infectious agents may be involved in the pathogenesis of this disorder. We therefore investigated whether exposure to pathogens that can infect the central nervous system is increased in patients with postpartum psychosis.
We measured the prevalence and titers of immunoglobulin G (IgG) and M (IgM) to herpes simplex virus type 1 (HSV-1) and 2 (HSV-2), Epstein-Barr virus (EBV), cytomegalovirus (CMV) and Toxoplasma Gondii (TG) in a cohort of patients with postpartum psychosis (n = 81) and compared these to matched postpartum controls.
We did not find significant differences in seroprevalence or antibody titers for any of these pathogens.
Limitations of this study include the indirect measurement of infectious disease and the cross-sectional design.
Our results do not support the hypothesis that exposure to these neurotropic pathogens is involved in postpartum psychosis.
由于产后精神病与免疫系统的激活有关，因此有人假设感染因子可能参与了这种疾病的发病机制。因此，我们研究了产后精神病患者是否存在中枢神经系统感染病原体的暴露增加。
我们测量了一组产后精神病患者（n=81）和匹配的产后对照组中针对单纯疱疹病毒 1 型（HSV-1）和 2 型（HSV-2）、EB 病毒（EBV）、巨细胞病毒（CMV）和刚地弓形虫（TG）的免疫球蛋白 G（IgG）和 M（IgM）的流行率和滴度，并对这些进行了比较。
我们没有发现这些病原体的血清流行率或抗体滴度有显著差异。
本研究的局限性包括传染病的间接测量和横断面设计。
我们的结果不支持接触这些嗜神经病原体与产后精神病有关的假设。
