Levin E R, Sharp B, Drayer J I, Weber M A
Am J Med Sci. 1985 Aug;290(2):70-2. doi: 10.1097/00000441-198508000-00005.
To evaluate the role of endogenous opioid peptides in regulating the blood pressure of hypertensive individuals, we administered the opiate antagonist, naloxone. One individual developed a severe hypertensive response, mean arterial pressure rising from a baseline of 107 mmHg to 147 mmHg 145 min after naloxone injection and infusion. After stopping naloxone, his blood pressure rapidly returned to baseline. Re-challenge with naloxone and clonidine resulted in a modest reduction of blood pressure in contrast to the profound hypotension induced by clonidine alone during a third session. Thus, endogenous opioids appear to regulate blood pressure in some hypertensive patients and opiate antagonists must be administered with caution to these individuals.
为评估内源性阿片肽在调节高血压患者血压中的作用，我们给予了阿片拮抗剂纳洛酮。一名患者出现了严重的高血压反应，纳洛酮注射及输注145分钟后，平均动脉压从基线107 mmHg升至147 mmHg。停止使用纳洛酮后，其血压迅速恢复至基线水平。与第三次给药时单独使用可乐定引起的严重低血压相比，再次给予纳洛酮和可乐定导致血压适度降低。因此，内源性阿片类物质似乎在某些高血压患者中调节血压，必须谨慎地给这些患者使用阿片拮抗剂。
