1Faculty of Medicine and Life Sciences,University of Tampere,Tampere,Finland.
4Department of Psychiatry,Kanta-Häme Hospital District,Hämeenlinna,Finland.
Acta Neuropsychiatr. 2018 Jun;30(3):168-174. doi: 10.1017/neu.2017.37. Epub 2018 Jan 9.
We investigated the separate effects of and possible interactions between the functional polymorphisms of brain-derived neurotrophic factor (BDNF) rs11030101, BDNF rs61888800, and neuregulin-1 (NRG1) rs3924999 and NRG1 rs6994992 on change of temperament scores in a clinical sample of subjects with major depression (MDD), who received selective serotonin reuptake inhibitor treatment for a period of 6 weeks.
The study population consisted of 98 Finnish individuals with MDD. They were assessed by the 107-item Temperament and Character Inventory temperament questionnaire (version IX) and the Montgomery-Åsberg Depression Rating Scale (MADRS). In general linear univariate models (GLM) for novelty seeking (NS) or reward dependence (RD) change age, gender, MADRS score change and BDNF and NRG1 genotypes were used as explaining explanatory variables.
Mean comparisons between corresponding temperament dimensions and genotypes showed significant differences between NS change and BDNF rs61888800 T-carrying status (mean difference: GG 0.30, GT/TT 2.47, p=0.022, t-test) and between RD change and NRG1 rs3924999 A-carrying status (mean difference: GG 1.21, GA/AA -0.33, p=0.003). In GLM models for NS change the significant predictors comprised BDNF rs61888800 T-carrying status, age and MADRS score change (model 1), and additionally NRG1 rs6994992 T-carrying status (model 2). For RD change the predictors included NRG1 rs3924999 A-carrying status, age and MADRS score change (model 1) and additionally gender (model 2).
According to the current results both BDNF and NRG1 are associated with temperament traits during depression. These results warrant further studies regarding the impact of this association on depression recovery.
我们研究了脑源性神经营养因子（BDNF）rs11030101、BDNF rs61888800 和神经调节蛋白 1（NRG1）rs3924999 和 NRG1 rs6994992 的功能多态性对接受选择性 5-羟色胺再摄取抑制剂治疗 6 周的重度抑郁症（MDD）患者的气质评分变化的单独影响及其可能的相互作用。
研究人群由 98 名芬兰 MDD 患者组成。他们通过 107 项气质和性格量表（第九版）和蒙哥马利-阿斯伯格抑郁评定量表（MADRS）进行评估。在新奇寻求（NS）或奖赏依赖（RD）变化的一般线性单变量模型（GLM）中，年龄、性别、MADRS 评分变化以及 BDNF 和 NRG1 基因型作为解释性变量。
对应气质维度和基因型之间的均值比较显示，NS 变化与 BDNF rs61888800 T 携带状态之间存在显著差异（均值差异：GG 0.30，GT/TT 2.47，p=0.022，t 检验），RD 变化与 NRG1 rs3924999 A 携带状态之间存在显著差异（均值差异：GG 1.21，GA/AA -0.33，p=0.003）。在 NS 变化的 GLM 模型中，显著的预测因子包括 BDNF rs61888800 T 携带状态、年龄和 MADRS 评分变化（模型 1），以及 NRG1 rs6994992 T 携带状态（模型 2）。RD 变化的预测因子包括 NRG1 rs3924999 A 携带状态、年龄和 MADRS 评分变化（模型 1）以及性别（模型 2）。
根据目前的结果，BDNF 和 NRG1 均与抑郁期间的气质特征有关。这些结果需要进一步研究这种关联对抑郁恢复的影响。
