University of Tampere, Medical School, 33014 Tampere, Finland.
Eur Psychiatry. 2012 May;27(4):245-9. doi: 10.1016/j.eurpsy.2010.07.006. Epub 2010 Oct 8.
The Temperament and Character Inventory (TCI) is commonly used in adult populations. Our aim was to explore: (1) if there are specific differences in temperament dimensions related to depression in comparison with general population, (2) if the treatment response during the acute phase of major depressive disorder (MDD) is predictable by TCI temperament dimensions.
Temperament profiles in 98 MDD patients were compared with a Finnish community sample. The patients were treated with serotonin selective reuptake inhibitors (SSRIs) for 6 weeks and their temperament profiles were assessed at baseline and endpoint. The harm avoidance (HA) and depression scores at baseline and endpoint were modelled with path analysis. For path modelling, we tested the relationships between different temperament dimensions and depression symptoms and other clinical variables with Mancova model.
The HA scores were significantly higher in patients both at baseline and endpoint compared to the Northern Finland 1966 Birth Cohort (NFBC). The patients, and especially males, had slightly higher reward dependency (RD) scores. HA at endpoint explained moderately the Montgomery Åsberg Depression Rating Scale (MADRS) endpoint score. HA endpoint score was strongly explained by HA baseline score.
HA is associated with risk of and treatment response to depression.
特质和性格问卷（TCI）常用于成年人群。我们的目的是探讨：（1）与一般人群相比，抑郁相关的气质维度是否存在特定差异；（2）TCI 气质维度是否可预测重度抑郁症（MDD）急性期的治疗反应。
将 98 例 MDD 患者的气质特征与芬兰社区样本进行比较。患者接受选择性 5-羟色胺再摄取抑制剂（SSRIs）治疗 6 周，并在基线和终点评估其气质特征。采用路径分析对伤害回避（HA）和基线及终点的抑郁评分进行建模。对于路径建模，我们使用曼科瓦模型测试了不同气质维度与抑郁症状和其他临床变量之间的关系。
与芬兰 1966 年出生队列（NFBC）相比，患者的 HA 评分在基线和终点均显著升高。患者，尤其是男性，RD 评分略高。终点时的 HA 可中度解释蒙哥马利抑郁评定量表（MADRS）终点评分。HA 终点评分可强烈解释 HA 基线评分。
HA 与抑郁的风险和治疗反应相关。
