Kavanagh F G, Hasan W, Smyth D A, Fenton J E
Department of Otolaryngology, Head and Neck Surgery,University Hospital Limerick,Ireland.
Department of Otolaryngology, Head and Neck Surgery,University Hospital Waterford,Ireland.
J Laryngol Otol. 2018 Mar;132(3):236-239. doi: 10.1017/S0022215117002444. Epub 2018 Jan 9.
To explore the link between nasal polyposis, refractory otitis media with effusion and eosinophilic granulomatosis with polyangiitis.
A retrospective observational study was carried out of patients diagnosed with refractory otitis media with effusion necessitating grommet insertion and who had nasal polyps. Patients were evaluated to determine if they fulfilled the diagnostic criteria of eosinophilic granulomatosis with polyangiitis.
Sixteen patients (10 males and 6 females) were identified. The mean age of grommet insertion was 45.4 years. The mean number of grommets inserted per patient was 1.6. The mean number of nasal polypectomies was 1.7. All 16 patients had paranasal sinus abnormalities and otitis media with effusion, 14 had asthma, 9 had serological eosinophilia and 7 had extravascular eosinophilia. Nine patients met the diagnostic criteria for eosinophilic granulomatosis with polyangiitis.
The co-presence of nasal polyps and resistant otitis media with effusion should raise the possibility of eosinophilic granulomatosis with polyangiitis.
探讨鼻息肉、难治性分泌性中耳炎与嗜酸性肉芽肿性多血管炎之间的联系。
对诊断为需行鼓膜切开置管术的难治性分泌性中耳炎且患有鼻息肉的患者进行一项回顾性观察研究。对患者进行评估，以确定他们是否符合嗜酸性肉芽肿性多血管炎的诊断标准。
共纳入16例患者（10例男性和6例女性）。鼓膜切开置管术的平均年龄为45.4岁。每位患者鼓膜切开置管的平均次数为1.6次。鼻息肉切除术的平均次数为1.7次。所有16例患者均有鼻窦异常和分泌性中耳炎，14例有哮喘，9例有血清嗜酸性粒细胞增多，7例有血管外嗜酸性粒细胞增多。9例患者符合嗜酸性肉芽肿性多血管炎的诊断标准。
鼻息肉与难治性分泌性中耳炎并存应提高嗜酸性肉芽肿性多血管炎的可能性。
