肌肉减少症与癌症患者接受食管切除术的发病率、死亡率或复发率无关。
Sarcopenia is not associated with morbidity, mortality, or recurrence after esophagectomy for cancer.
机构信息
Oregon Health & Science University, Department of Surgery, 3181 SW Sam Jackson Park Rd, Mail Code L223, Portland, OR 97239, USA.
Oregon Health & Science University, Department of Diagnostic Radiology, 3181 SW Sam Jackson Park Road, Mail Code 340, Portland, OR 97239, USA.
出版信息
Am J Surg. 2018 May;215(5):813-817. doi: 10.1016/j.amjsurg.2017.12.017. Epub 2018 Jan 4.
BACKGROUND
Sarcopenia is associated with increased morbidity and mortality in hepatic, pancreatic and colorectal cancer. We examined the effect of sarcopenia on morbidity, mortality, and recurrence after resection for esophageal cancer.
METHODS
Retrospective review of consecutive esophagectomies from 2010 to 2015. Computed tomography studies were analyzed for sarcopenia. Morbidity was analyzed using Fischer's test and survival data with Kaplan Meier curves.
RESULTS
The sarcopenic group (n = 127) had lower BMI, later stage disease, and higher incidence of neoadjuvant radiation than those without sarcopenia (n = 46). There were no differences in morbidity or mortality between the groups (p = .75 and p = .31, respectively). Mean length of stay was similar (p = .70). Disease free and overall survival were similar (p = .20 and p = .39, respectively).
CONCLUSION
There is no association between sarcopenia and increased morbidity, mortality and disease-free survival in patients undergoing esophagectomy for cancer. Sarcopenia in esophageal cancer may not portend worse outcomes that have been reported in other solid tumors.
背景
肌肉减少症与肝、胰和结直肠癌的发病率和死亡率增加有关。我们研究了肌肉减少症对食管癌切除术后发病率、死亡率和复发的影响。
方法
回顾性分析 2010 年至 2015 年连续进行的食管切除术。对计算机断层扫描研究进行了肌肉减少症分析。使用费舍尔检验分析发病率，使用 Kaplan-Meier 曲线分析生存数据。
结果
肌肉减少症组（n=127）的 BMI 较低，疾病分期较晚，且新辅助放疗的发生率高于无肌肉减少症组（n=46）。两组之间的发病率或死亡率无差异（p=0.75 和 p=0.31）。平均住院时间相似（p=0.70）。无病生存率和总生存率相似（p=0.20 和 p=0.39）。
结论
在接受食管癌切除术的患者中，肌肉减少症与发病率、死亡率和无病生存率增加之间没有关联。在其他实体瘤中报道的肌肉减少症与预后不良之间可能没有关联。
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