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用于慢性乙型肝炎病毒感染患者前核心区和核心启动子基础突变常规检测的桑格测序法与INNO-LiPA® HBV前核心检测法的比较

Sanger sequencing versus INNO-LiPA® HBV PreCore assay for routine detection of precore and basal core promoter mutations in hepatitis virus B chronically infected patients.

作者信息

Alidjinou E K, Bocket L, Pigot V, Lambert V, Hallaert C, Canva V, Hober D

机构信息

Univ Lille, Faculté de Médecine, CHU Lille, Laboratoire de Virologie EA3610, F-59000, Lille, France.

Univ Lille, Faculté de Médecine, CHU Lille, Laboratoire de Virologie EA3610, F-59000, Lille, France.

出版信息

Diagn Microbiol Infect Dis. 2018 Apr;90(4):277-279. doi: 10.1016/j.diagmicrobio.2017.12.006. Epub 2017 Dec 17.

DOI:10.1016/j.diagmicrobio.2017.12.006
PMID:29310947
Abstract

We compared the Sanger sequencing and the commercial INNO-LiPA® HBV assay for the routine detection of precore (PC) and basal core promoter (BCP) mutations of hepatitis B virus in chronically infected patients. The overall agreement rate between assays was 94.2% and 98.8% for the detection of PC and BCP mutations, respectively.

摘要

我们比较了桑格测序法和商业INNO-LiPA® HBV检测法，用于慢性感染患者中乙肝病毒前核心（PC）和核心启动子（BCP）突变的常规检测。两种检测方法在检测PC和BCP突变方面的总体一致率分别为94.2%和98.8%。

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