Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Jiangsu, China.
Institute of Epidemiology and Microbiology, Huadong Research Institute for Medicine and Biotechnics, Jiangsu, China.
Sci Rep. 2018 Jan 8;8(1):104. doi: 10.1038/s41598-017-18463-y.
Polymorphisms within NF-κB pathway genes may be linked to hepatitis C virus (HCV) infection susceptibility and outcomes. We investigated the associations between single nucleotide polymorphisms (SNPs) in NF-κB and the susceptibility as well as resolution of HCV infection. A Chinese population, including 1125 uninfected control cases, 558 cases with spontaneous viral clearance and 898 cases with persistent HCV infection, was genotyped for four SNPs (rs11820062, rs230530, rs1056890 and rs3774963) using a TaqMan assay. Our logistic analyses indicate that the subjects carrying RelA rs11820062 A allele had a significantly increased risk of HCV susceptibility (P < 0.003125 in a dominant or additive model). In stratified analysis, the increased risk associated with rs11820062 A allele on HCV susceptibility remained in some case subgroups. This study demonstrates that a genetic variant involved in the NF-κB pathway gene (rs11820062 A allele) is associated with an increased HCV susceptibility within a high-risk Chinese population.
NF-κB 通路基因中的多态性可能与丙型肝炎病毒（HCV）感染易感性和结局有关。我们研究了 NF-κB 中单核苷酸多态性（SNPs）与 HCV 感染易感性和清除的关系。采用 TaqMan 法对包括 1125 例未感染对照病例、558 例自发性病毒清除病例和 898 例持续性 HCV 感染病例在内的中国人群进行了四个 SNPs（rs11820062、rs230530、rs1056890 和 rs3774963）的基因分型。我们的逻辑分析表明，携带 RelA rs11820062 A 等位基因的个体患 HCV 易感性的风险显著增加（显性或加性模型中 P < 0.003125）。分层分析显示，rs11820062 A 等位基因与 HCV 易感性相关的风险在一些病例亚组中仍然存在。本研究表明，NF-κB 通路基因中的遗传变异（rs11820062 A 等位基因）与高危中国人群中 HCV 易感性增加有关。
