• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

红细胞分布宽度升高预示肝门部胆管癌预后不良。

Elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma.

作者信息

Li Bei, You Zhen, Xiong Xian-Ze, Zhou Yong, Wu Si-Jia, Zhou Rong-Xing, Lu Jiong, Cheng Nan-Sheng

机构信息

Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.

出版信息

Oncotarget. 2017 Nov 25;8(65):109468-109477. doi: 10.18632/oncotarget.22694. eCollection 2017 Dec 12.

DOI:10.18632/oncotarget.22694
PMID:29312621
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5752534/
Abstract

BACKGROUND

Although the red blood cell distribution width (RDW) has been reported as a reliable predictor of prognosis in several types of cancer, the prognostic value of RDW in hilar cholangiocarcinoma (HC) has not been studied.

METHODS

A retrospective analysis of 292 consecutively recruited HC patients undergoing radical resection was conducted. The optimal cutoff value of RDW was determined by the receiver operating characteristic curve (ROC). Survival analysis by the Kaplan-Meier method, the difference between the clinico-pathologic variables and survival were evaluated by log-rank analysis. Multivariate analysis identified independent prognostic risk factors of overall survival (OS).

RESULTS

ROC analysis suggested that the optimal cutoff value for the RDW was 14.95. Linear correlation analysis revealed that RDW is associated with white blood cell count (P = 0.007), neutrophil-to-lymphocyte ratio (P = 0.02), and hemoglobin (P < 0.001), albumin (P < 0.001). In a multivariate analysis, the RDW was an independent prognostic factor for OS (HR = 1.755, 95% CI 1.311-2.349, P < 0.001).

CONCLUSIONS

Elevated RDW may be regarded as an indicator of systemic inflammatory response which might facilitate HC growth and metastasis. Current evidence suggests that RDW may have clinical significance in predicting OS after surgery in HC patients.

摘要

背景

尽管红细胞分布宽度（RDW）已被报道为多种癌症预后的可靠预测指标，但RDW在肝门部胆管癌（HC）中的预后价值尚未得到研究。

方法

对292例连续招募的接受根治性切除的HC患者进行回顾性分析。通过受试者工作特征曲线（ROC）确定RDW的最佳截断值。采用Kaplan-Meier法进行生存分析，通过对数秩检验评估临床病理变量与生存之间的差异。多因素分析确定总生存（OS）的独立预后危险因素。

结果

ROC分析表明，RDW的最佳截断值为14.95。线性相关分析显示，RDW与白细胞计数（P = 0.007）、中性粒细胞与淋巴细胞比值（P = 0.02）、血红蛋白（P < 0.001）、白蛋白（P < 0.001）相关。在多因素分析中，RDW是OS的独立预后因素（HR = 1.755，95%CI 1.311 - 2.349，P < 0.001）。

结论

RDW升高可能被视为全身炎症反应的指标，这可能促进HC的生长和转移。目前的证据表明，RDW在预测HC患者术后OS方面可能具有临床意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa0/5752534/955af4689625/oncotarget-08-109468-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa0/5752534/d6bf19fc295b/oncotarget-08-109468-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa0/5752534/9404aaca2dbe/oncotarget-08-109468-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa0/5752534/955af4689625/oncotarget-08-109468-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa0/5752534/d6bf19fc295b/oncotarget-08-109468-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa0/5752534/9404aaca2dbe/oncotarget-08-109468-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa0/5752534/955af4689625/oncotarget-08-109468-g003.jpg

相似文献

1
Elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma.红细胞分布宽度升高预示肝门部胆管癌预后不良。
Oncotarget. 2017 Nov 25;8(65):109468-109477. doi: 10.18632/oncotarget.22694. eCollection 2017 Dec 12.
2
Elevated platelet distribution width predicts poor prognosis in hilar cholangiocarcinoma.血小板分布宽度升高预示肝门部胆管癌预后不良。
Medicine (Baltimore). 2020 Mar;99(12):e19400. doi: 10.1097/MD.0000000000019400.
3
Preoperatively elevated RDW-SD and RDW-CV predict favorable survival in intrahepatic cholangiocarcinoma patients after curative resection.术前升高的红细胞分布宽度标准差和红细胞分布宽度变异系数可预测肝内胆管癌患者根治性切除术后的良好生存。
BMC Surg. 2021 Mar 1;21(1):105. doi: 10.1186/s12893-021-01094-6.
4
Elevated red blood cell distribution width predicts poor prognosis in patients with oral squamous cell carcinoma.红细胞分布宽度升高预示口腔鳞状细胞癌患者预后不良。
Cancer Manag Res. 2018 Sep 17;10:3611-3618. doi: 10.2147/CMAR.S176200. eCollection 2018.
5
The usefulness of red blood cell distribution width and its ratio with platelet count in breast cancer after surgery and adjuvant treatment: a retrospective study.红细胞分布宽度及其与血小板计数的比值在乳腺癌术后辅助治疗中的应用价值：一项回顾性研究。
Gland Surg. 2022 Dec;11(12):1864-1873. doi: 10.21037/gs-22-410.
6
Preoperative red cell distribution width and neutrophil-to-lymphocyte ratio predict survival in patients with epithelial ovarian cancer.术前红细胞分布宽度和中性粒细胞与淋巴细胞比值可预测上皮性卵巢癌患者的生存情况。
Sci Rep. 2017 Feb 22;7:43001. doi: 10.1038/srep43001.
7
Red blood cell distribution width and platelet counts are independent prognostic factors and improve the predictive ability of IPI score in diffuse large B-cell lymphoma patients.红细胞分布宽度和血小板计数是独立的预后因素，并可提高弥漫性大 B 细胞淋巴瘤患者 IPI 评分的预测能力。
BMC Cancer. 2019 Nov 11;19(1):1084. doi: 10.1186/s12885-019-6281-1.
8
The Predictive Value of Red Cell Distribution Width and Red Cell Distribution Width to Erythrocyte Count Ratio for Adverse Cardiovascular Events During the Hospitalization of Patients of ST-segment Elevation Myocardial Infarction.红细胞分布宽度及红细胞分布宽度与红细胞计数比值对ST段抬高型心肌梗死患者住院期间不良心血管事件的预测价值
Clin Lab. 2020 Jul 1;66(7). doi: 10.7754/Clin.Lab.2019.191123.
9
Clinical Utility of Red Blood Cell Distribution Width for the Diagnosis and Prognosis of Cervical Cancer.红细胞分布宽度在宫颈癌诊断和预后中的临床应用
Int J Gen Med. 2022 Mar 6;15:2597-2606. doi: 10.2147/IJGM.S354569. eCollection 2022.
10
The Relationship Between Red Cell Distribution Width and Cancer-Specific Survival in Patients With Renal Cell Carcinoma Treated With Partial and Radical Nephrectomy.红细胞分布宽度与接受部分和根治性肾切除术治疗的肾癌患者癌症特异性生存的关系。
Clin Genitourin Cancer. 2018 Jun;16(3):e677-e683. doi: 10.1016/j.clgc.2017.12.003. Epub 2017 Dec 27.

引用本文的文献

1
Clinical relevance of the red blood cell distribution width measured preoperatively as a prognostic marker in patients with distal cholangiocarcinoma undergoing pancreaticoduodenectomy.术前测量的红细胞分布宽度作为接受胰十二指肠切除术的远端胆管癌患者预后标志物的临床相关性。
Surg Today. 2025 Mar 29. doi: 10.1007/s00595-025-03005-1.
2
A Comprehensive Nomogram Combining CT Imaging with Clinical Features for Prediction of Lymph Node Metastasis in Stage I-IIIB Non-small Cell Lung Cancer.一种结合CT成像与临床特征的综合列线图，用于预测Ⅰ-ⅢB期非小细胞肺癌的淋巴结转移
Ther Innov Regul Sci. 2022 Jan;56(1):155-167. doi: 10.1007/s43441-021-00345-1. Epub 2021 Oct 26.
3

本文引用的文献

1
Prognostic significance of red blood cell distribution width in gastrointestinal disorders.红细胞分布宽度在胃肠道疾病中的预后意义
World J Gastroenterol. 2017 Jul 21;23(27):4879-4891. doi: 10.3748/wjg.v23.i27.4879.
2
Prognostic value of red blood cell distribution width in hepatocellular carcinoma.红细胞分布宽度在肝细胞癌中的预后价值
Ann Transl Med. 2017 Jul;5(13):271. doi: 10.21037/atm.2017.06.30.
3
Preoperative red cell distribution width and neutrophil-to-lymphocyte ratio predict survival in patients with epithelial ovarian cancer.
Prognostic Value of the Red Cell Distribution Width in Patients with Sepsis-Induced Acute Respiratory Distress Syndrome: A Retrospective Cohort Study.
红细胞分布宽度对脓毒症相关性急性呼吸窘迫综合征患者预后的预测价值：一项回顾性队列研究。
Dis Markers. 2021 Jun 2;2021:5543822. doi: 10.1155/2021/5543822. eCollection 2021.
4
Prognostic significance of red blood cell distribution width in gastrointestinal cancers: A meta-analysis.红细胞分布宽度在胃肠道癌症中的预后意义：一项荟萃分析。
Medicine (Baltimore). 2020 Apr;99(16):e19588. doi: 10.1097/MD.0000000000019588.
5
Red blood cell distribution width and platelet counts are independent prognostic factors and improve the predictive ability of IPI score in diffuse large B-cell lymphoma patients.红细胞分布宽度和血小板计数是独立的预后因素，并可提高弥漫性大 B 细胞淋巴瘤患者 IPI 评分的预测能力。
BMC Cancer. 2019 Nov 11;19(1):1084. doi: 10.1186/s12885-019-6281-1.
6
Prognostic role of pretreatment red blood cell distribution width in patients with cancer: A meta-analysis of 49 studies.治疗前红细胞分布宽度在癌症患者中的预后作用：49项研究的荟萃分析
J Cancer. 2019 Jul 10;10(18):4305-4317. doi: 10.7150/jca.31598. eCollection 2019.
7
Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma.红细胞分布宽度与套细胞淋巴瘤患者结局的相关性。
Cancer Med. 2019 Jun;8(6):2751-2758. doi: 10.1002/cam4.2155. Epub 2019 Apr 13.
8
Combining Red Blood Cell Distribution Width (RDW-CV) and CEA Predict Poor Prognosis for Survival Outcomes in Colorectal Cancer.红细胞分布宽度（RDW-CV）与癌胚抗原（CEA）联合检测对结直肠癌生存预后的预测价值较差。
J Cancer. 2019 Jan 29;10(5):1162-1170. doi: 10.7150/jca.29018. eCollection 2019.
术前红细胞分布宽度和中性粒细胞与淋巴细胞比值可预测上皮性卵巢癌患者的生存情况。
Sci Rep. 2017 Feb 22;7:43001. doi: 10.1038/srep43001.
4
Clinical and prognostic significance of anisocytosis measured as a red cell distribution width in patients with colorectal cancer.红细胞分布宽度作为一项指标在结直肠癌患者中用于评估临床和预后的意义。
QJM. 2017 Jun 1;110(6):361-367. doi: 10.1093/qjmed/hcw223.
5
Surgical treatment of perihilar cholangiocarcinoma: early results of en bloc portal vein resection.肝门部胆管癌的手术治疗：整块门静脉切除的早期结果
Langenbecks Arch Surg. 2017 Feb;402(1):95-104. doi: 10.1007/s00423-016-1542-9. Epub 2016 Dec 23.
6
Role of interleukin-6 in cancer progression and therapeutic resistance.白细胞介素-6在癌症进展和治疗耐药中的作用。
Tumour Biol. 2016 Sep;37(9):11553-11572. doi: 10.1007/s13277-016-5098-7. Epub 2016 Jun 3.
7
Level of red cell distribution width is affected by various factors.红细胞分布宽度水平受多种因素影响。
Clin Chem Lab Med. 2016 Dec 1;54(12):e387. doi: 10.1515/cclm-2016-0195.
8
Elevated red blood cell distribution width is associated with liver function tests in patients with primary hepatocellular carcinoma.红细胞分布宽度升高与原发性肝细胞癌患者的肝功能检查相关。
Clin Hemorheol Microcirc. 2016 Nov 25;64(2):149-155. doi: 10.3233/CH-162053.
9
A Nomogram to Predict Prognostic Value of Red Cell Distribution Width in Patients with Esophageal Cancer.预测食管癌患者红细胞分布宽度预后价值的列线图
Mediators Inflamm. 2015;2015:854670. doi: 10.1155/2015/854670. Epub 2015 Oct 12.
10
Is early detection of colon cancer possible with red blood cell distribution width?红细胞分布宽度能否实现结肠癌的早期检测？
Asian Pac J Cancer Prev. 2015;16(2):753-6. doi: 10.7314/apjcp.2015.16.2.753.