Degree of Resection and Ki-67 Labeling Index for Recurring Meningiomas.

Objective Meningioma recurrence after resection is likely influenced by multiple surgical and histologic factors. In this study, the degree of resection and tumor immunoreactivity to MIB-1 (i.e., Ki-67 labeling index (LI)) are described in recurrent and non-recurrent meningioma cases. Methods Data regarding tumor location, the degree of resection, histologic features, and the degree of Ki-67 positivity were collected for 32 patients treated between September 2008 and July 2009. Follow-up for recurrence was assessed through five years. Results A total of 32 patients (13 males; 19 females) underwent resection. The mean age was 53.3 years. Gross total resection (GTR) occurred in 25 (78.1%) cases. Near-total resection (NTR) occurred in five (15.6%) cases. Subtotal resection (STR) occurred in two (6.2%) cases. The overall mean Ki-67 LI score was 9.75% (ranging between 1% to 48%). The mean Ki-67 LI for GTR, NTR, and STR cases were 8.0%, 10.2%, and 29.5% respectively. Tumor recurrence occurred in five (15.6%) patients. The mean Ki-67 LI for recurrence lesions was 22.2%. Conclusion We present our descriptive data for Ki-67 LI for initial tumors and recurrence. The risk of recurrence following resection of meningiomas may be associated with the degree of Ki-67 positivity.