a Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Pampa-Campus Uruguaiana , Uruguaiana , RS , Brasil.
b Programa de Pós Graduação em Bioquímica, Universidade Federal do Pampa-Campus Uruguaiana , Uruguaiana , RS , Brasil.
J Am Coll Nutr. 2018 Mar-Apr;37(3):209-214. doi: 10.1080/07315724.2017.1386139. Epub 2018 Jan 9.
The current nutritional transition process contributes further to accelerate the onset of metabolic disorders, as do a number of environmental factors that lead to the diagnosis of chronic diseases, as a diet of low nutritional value, is possibly related to the incidence of metabolic syndrome. In addition to these factors, metabolic syndrome may also be related to genetic factors, the ADIPOQ + 45T> G polymorphism has been associated with serum adiponectin levels, insulin sensitivity, and obesity, which affects adiponectin levels act as protective factor for cardiovascular disease. In this way, the present study aimed to analyze the possible association between the ADIPOQ + 45T> G gene polymorphism, usual diet and metabolic syndrome in the elderly.
We evaluated inflammatory and biochemical markers compared with older age groups (age 60 years) with and without metabolic syndrome. In addition to the anthropometric measurements of weight, height and waist circumference, the ADIPOQ + 45T> G gene polymorphism was determined by PCR- RFLP, and food consumption was investigated using a food frequency questionnaire.
The study included 111 elderly individuals. Our main results show that there was a significant relationship between the habitual consumption of milk for the group that had metabolic syndrome (p < 0.05). HDL-c levels, glucose, triglycerides, diastolic blood pressure and weight, height and waist circumference had to be altered in patients with metabolic syndrome. There was an association between habitual dietary intake of white meat with haplotypes TG and GG.
We conclude that the relationship between the habitual consumption of certain food groups and ADIPOQ indicates the need for further studies to develop a better understanding of this relationship; however, there was no association between the ADIPOQ + 45T> G gene polymorphism and metabolic syndrome in the group of elderly studied.
当前的营养转型过程进一步加速了代谢紊乱的发生，许多环境因素也导致了慢性疾病的诊断，因为低营养价值的饮食可能与代谢综合征的发生有关。除了这些因素，代谢综合征也可能与遗传因素有关，ADIPOQ+45T>G 多态性与血清脂联素水平、胰岛素敏感性和肥胖有关，脂联素水平的变化可作为心血管疾病的保护因素。因此，本研究旨在分析 ADIPOQ+45T>G 基因多态性、常规饮食与老年人代谢综合征之间的可能相关性。
我们评估了炎症和生化标志物，比较了有和没有代谢综合征的老年年龄组（60 岁）。除了体重、身高和腰围的人体测量外，还通过 PCR-RFLP 确定了 ADIPOQ+45T>G 基因多态性，并使用食物频率问卷调查了食物消耗情况。
本研究纳入了 111 名老年人。我们的主要结果表明，代谢综合征组习惯性食用牛奶与（p<0.05）有显著关系。HDL-c 水平、葡萄糖、甘油三酯、舒张压和体重、身高和腰围在代谢综合征患者中发生了改变。习惯性食用白肉与 TG 和 GG 单倍型之间存在关联。
我们得出结论，习惯性食用某些食物组与 ADIPOQ 之间的关系表明需要进一步研究，以更好地了解这种关系；然而，在研究的老年人群中，ADIPOQ+45T>G 基因多态性与代谢综合征之间没有关联。
