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Normocytic Normochromic Anaemia and Asymptomatic Neutropenia in a 40-Day-Old Infant Breastfed by an Epileptic Mother Treated With Lamotrigine: Infant's Adverse Drug Reaction.

作者信息

Bedussi Francesca, Relli Valentina, Faraoni Lorella, Eleftheriou Georgios, Giampreti Andrea, Gallo Mariapina, Lorenzi Federica, Sangiovanni Anna, Chiara Francesca, Maccioni Rosella, Pilloni Pier P, Falchi Giovanna, Scanu Mariapiera, Butera Raffaella, Bacis Giuseppe

机构信息

Poison Centre and Teratology Information Service, Papa Giovanni XXIII Hospital, Bergamo.

Department of Pediatrics, Iglesias C.T.O. Hospital Centre, ASSL Carbonia, Italy.

出版信息

J Paediatr Child Health. 2018 Jan;54(1):104-105. doi: 10.1111/jpc.13805.

DOI:10.1111/jpc.13805
PMID:29314386
Abstract
摘要

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Normocytic Normochromic Anaemia and Asymptomatic Neutropenia in a 40-Day-Old Infant Breastfed by an Epileptic Mother Treated With Lamotrigine: Infant's Adverse Drug Reaction.一名40日龄母乳喂养婴儿,其母亲为癫痫患者且正在服用拉莫三嗪,出现正细胞正色素性贫血和无症状中性粒细胞减少症:婴儿的药物不良反应
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Evaluate the effects of antiepileptic drugs on reproductive endocrine system in newly diagnosed female epileptic patients receiving either Valproate or Lamotrigine monotherapy: A prospective study.评估丙戊酸盐或拉莫三嗪单药治疗新诊断女性癫痫患者时抗癫痫药物对生殖内分泌系统的影响:一项前瞻性研究。
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引用本文的文献

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Breastfed infants exposed to lamotrigine faced a low risk of toxic effects.接受拉莫三嗪治疗的母乳喂养婴儿出现毒性作用的风险较低。
Acta Paediatr. 2025 Feb;114(2):346-354. doi: 10.1111/apa.17432. Epub 2024 Sep 20.
2
Medicines postpartum in Sweden and coverage in Janusmed Breastfeeding.瑞典的产后用药和 Janusmed Breastfeeding 中的覆盖范围。
Eur J Clin Pharmacol. 2023 Sep;79(9):1261-1269. doi: 10.1007/s00228-023-03528-x. Epub 2023 Jul 15.
3
Management of anti-seizure medications in lactating women with epilepsy.癫痫哺乳期妇女抗癫痫药物的管理
Front Neurol. 2022 Nov 17;13:1005890. doi: 10.3389/fneur.2022.1005890. eCollection 2022.
4
Incorporating Breastfeeding-Related Variability with Physiologically Based Pharmacokinetic Modeling to Predict Infant Exposure to Maternal Medication Through Breast Milk: a Workflow Applied to Lamotrigine.将与母乳喂养相关的变异性与基于生理学的药代动力学模型相结合,以预测通过母乳中母亲用药对婴儿的暴露:应用于拉莫三嗪的工作流程。
AAPS J. 2021 May 17;23(4):70. doi: 10.1208/s12248-021-00599-5.