Rab35 GTPase 与癌症：将膜转运与肿瘤发生联系起来。
Rab35 GTPase and cancer: Linking membrane trafficking to tumorigenesis.
机构信息
Membrane Traffic and Cell Division Lab, Cell Biology and Infection Department, Institut Pasteur, Paris, France.
Centre National de la Recherche Scientifique UMR3691, Paris, France.
出版信息
Traffic. 2018 Apr;19(4):247-252. doi: 10.1111/tra.12546. Epub 2018 Feb 11.
Rab35 is a small GTPase that is involved in many cellular processes, including membrane trafficking, cell polarity, lipid homeostasis, immunity, phagocytosis and cytokinesis. Recent studies showed that activating mutations confer Rab35 with oncogenic properties. Conversely, downregulation of Rab35 inverts apico-basal cell polarity and promotes cell migration. Here we review Rab35's known functions in membrane trafficking and signaling, cell division and cell migration in cancer cells and discuss the importance of Rab35-dependent membrane trafficking in cancer progression.
Rab35 是一种小 GTPase，参与许多细胞过程，包括膜运输、细胞极性、脂质稳态、免疫、吞噬作用和细胞分裂。最近的研究表明，激活突变赋予 Rab35 致癌特性。相反，Rab35 的下调会使细胞的顶底极性反转，并促进细胞迁移。本文综述了 Rab35 在癌细胞中的膜运输和信号转导、细胞分裂和细胞迁移中的已知功能，并讨论了 Rab35 依赖性膜运输在癌症进展中的重要性。
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