Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, West China Medical School, Sichuan University, 001 Forth Keyuan Road, 610041, Chengdu, P.R. China.
Department of Nuclear Medicine, West China Hospital, Sichuan University, Sichuan, 610041, P.R. China.
Chembiochem. 2018 Mar 16;19(6):530-534. doi: 10.1002/cbic.201700556. Epub 2018 Jan 30.
Strongly fluorogenic boron dipyrromethene (BODIPY)-tetrazine probes have been obtained by introducing an alkoxy tetrazine fragment at the boron center. The fluorescence signal from these probes strongly increases by up to 225-fold after reaction with bioorthogonal coupling partners, and the hydrophilicity of probes is improved, such that they are suitable for live-cell imaging.
强荧光性的硼二吡咯亚甲基（BODIPY）-四嗪探针通过在硼中心引入烷氧基四嗪片段而获得。这些探针与生物正交偶联物反应后，荧光信号大大增强，最高可达 225 倍，并且探针的亲水性得到改善，使其适用于活细胞成像。
