Saner H E, Gobel F L, Salomonowitz E, Erlien D A, Edwards J E
J Am Coll Cardiol. 1985 Nov;6(5):1096-9. doi: 10.1016/s0735-1097(85)80314-4.
Coronary atherosclerotic lesions are more often located eccentrically (70%) than concentrically (30%). In this study, the configuration of eccentric coronary artery atherosclerotic lesions was assessed by means of computerized planimetry in 100 specimens of eccentric arterial lesions. Special attention was given to the relation between the disease-free wall and the severity of obstruction. The mean disease-free wall are length measured between 17 and 23% of the total vessel circumference in eccentric coronary artery lesions that obstructed 50 to 90% of the cross-sectional area. This ratio persisted irrespective of the location of the lesion within the vessel and was not significantly different with vessels of different sizes. The presence of disease-free arcs of coronary artery wall as observed in this pathologic study may relate to three factors in clinical coronary artery disease: The published observations of spasm in segments of arteries harboring structural obstructive lesions may be explained by the frequent presence of uninvolved arcs of coronary artery walls. Multiple views during coronary arteriography are necessary to accurately reflect the degree of obstruction. The results of percutaneous transluminal coronary angioplasty may be influenced by both the disease-free arc and the atheromatous obstruction.
冠状动脉粥样硬化病变多呈偏心性（70%）而非同心性（30%）。在本研究中，通过计算机平面测量法对100例偏心性动脉病变标本中的偏心冠状动脉粥样硬化病变形态进行了评估。特别关注了无病变壁与阻塞严重程度之间的关系。在阻塞横截面积50%至90%的偏心冠状动脉病变中，无病变壁平均弧长占血管总周长的17%至23%。无论病变在血管内的位置如何，该比例均保持不变，且不同大小血管之间无显著差异。本病理学研究中观察到的冠状动脉壁无病变弧的存在可能与临床冠状动脉疾病的三个因素有关：在存在结构性阻塞病变的动脉节段中已发表的痉挛观察结果，可能因冠状动脉壁无病变弧的频繁存在而得到解释。冠状动脉造影时需要多个视角以准确反映阻塞程度。经皮腔内冠状动脉成形术的结果可能受无病变弧和动脉粥样硬化阻塞的影响。
