乙肝表面抗原阳性携带者母亲所生婴儿的乙肝病毒感染免疫预防

Immunoprophylaxis of infection with hepatitis B virus in infants born to hepatitis B surface antigen-positive carrier mothers.

作者信息

Lo K J, Tsai Y T, Lee S D, Wu T C, Wang J Y, Chen G H, Yeh C L, Chiang B N, Yeh S H, Goudeau A

出版信息

J Infect Dis. 1985 Oct;152(4):817-22. doi: 10.1093/infdis/152.4.817.

DOI:10.1093/infdis/152.4.817

Abstract

Infants born to carrier mothers positive for hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) received 5 micrograms of hepatitis B virus (HBV) vaccine on four occasions. Group 1 received vaccine only, group 2 received vaccine plus hepatitis B immune globulin (HBIG) at birth, and group 3 received vaccine plus HBIG at birth and at one month. Infants born to HBeAg-positive mothers (group 4) received a reduced dose of vaccine (2.5 micrograms) on three occasions as well as HBIG at birth. As compared with 78.4% of the control group (infants whose parents refused vaccination) who became chronic HBV carriers at the age of 14 months, the protective efficacy rate of vaccination was 75.3% in group 1,85.5% in group 2,89.7% in group 3, and 87.2% in group 4. HBV vaccine (5 micrograms) was also given to infants born to HBsAg-positive, HBeAg-negative mothers on four on four occasions. The antibody response to HBsAg in vaccine recipients was 12% after the first dose, 44% after the second dose, and 75% and 100% at six months and 1.5 years of age, respectively.

摘要

母亲为乙肝表面抗原（HBsAg）和乙肝e抗原（HBeAg）阳性携带者的婴儿分四次接种了5微克乙肝病毒（HBV）疫苗。第1组仅接种疫苗，第2组在出生时接种疫苗加乙肝免疫球蛋白（HBIG），第3组在出生时和1个月时接种疫苗加HBIG。母亲为HBeAg阳性的婴儿（第4组）分三次接种减量疫苗（2.5微克）并在出生时接种HBIG。与14个月龄时成为慢性HBV携带者的对照组（父母拒绝接种疫苗的婴儿）的78.4%相比，第1组的疫苗保护有效率为75.3%，第2组为85.5%，第3组为89.7%。第4组为87.2%。母亲为HBsAg阳性、HBeAg阴性的婴儿也分四次接种了5微克HBV疫苗。疫苗接种者对HBsAg的抗体应答在第一剂后为12%，第二剂后为44%，在6个月和1.5岁时分别为75%和100%。