一种新的锥体外系假定神经调节因子。
A new putative neuroregulator of the extrapyramidal system.
作者信息
Diamond B I, Borison R L
出版信息
Pharmacology. 1978;17(4):210-4. doi: 10.1159/000136856.
A putative neurotransmitter, 2-phenylethylamine, which is most highly concentrated in the extrapyramidal system of human brain, is able to reverse reserpine-induced parkinsonism in animals and elicit stereotypy. This action is only partially antagonized after catecholamine depletion by pretreatment with a-methyl-para-tyrosine, and fully blocked by pretreatment with haloperidol, a dopamine receptor blocker. Therefore, via direct and/or indirect actions, 2-phenylethylamine may serve a neuroregulatory role in the extrapyramidal system.
一种被认为是神经递质的2-苯乙胺，在人类大脑的锥体外系中浓度最高，它能够逆转利血平诱导的动物帕金森症并引发刻板行为。在用α-甲基对酪氨酸预处理使儿茶酚胺耗竭后，这种作用仅被部分拮抗，而用多巴胺受体阻滞剂氟哌啶醇预处理则可完全阻断。因此，2-苯乙胺可能通过直接和/或间接作用在锥体外系中发挥神经调节作用。
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