Winterling Jeanette, Johansson Eva, Wettergren Lena, Ljungman Per, Alexanderson Kristina
Division of Nursing, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.
Center of Haematology, Karolinska University Hospital, Stockholm, Sweden.
Eur J Cancer Care (Engl). 2018 Mar;27(2):e12808. doi: 10.1111/ecc.12808. Epub 2018 Jan 8.
This study examined occupational status and factors associated with sick leave and disability pension among adult long-term survivors previously treated with allogeneic stem cell transplantation (allo-SCT) during childhood. Moreover, occupational status was compared to that of a reference group. Data were collected with questionnaires and from medical records. The SCT group included 59 adults (18-45 years old: response rate 63%) treated with allo-SCT in childhood with a median of 17 (range 3-28) years earlier. The reference group included 296 individuals randomly selected from the general population. The results show that 54% of the long-term survivors were working part- or full-time and that 19% were on sick leave or disability pension. A larger proportion of the SCT group was on sick leave or disability pension (19% vs. 6%: p < .001) than of the reference group. The logistic regression analysis revealed that being on sick leave or disability pension among long-term survivors was associated with late effects related to the allo-SCT (OR 12.28: 95% CI 1.3-111.6: p = .03). The results underscore that long-term survivors' engagement in paid work is influenced many years after treatment and highlights the need to include vocational assistance in the rehabilitation following allo-SCT in childhood.
本研究调查了童年时期接受异基因干细胞移植（allo-SCT）治疗的成年长期存活者的职业状况以及与病假和残疾抚恤金相关的因素。此外，还将该组的职业状况与一个参照组进行了比较。通过问卷调查和医疗记录收集数据。SCT组包括59名成年人（18至45岁：应答率63%），他们在童年时期接受了allo-SCT治疗，时间中位数为17年（范围3至28年）。参照组包括从普通人群中随机选取的296人。结果显示，54%的长期存活者从事兼职或全职工作，19%的人休病假或领取残疾抚恤金。与参照组相比，SCT组中休病假或领取残疾抚恤金的比例更高（19%对6%：p < 0.001）。逻辑回归分析显示，长期存活者休病假或领取残疾抚恤金与allo-SCT的晚期效应相关（比值比12.28：95%置信区间1.3至111.6：p = 0.03）。结果强调，长期存活者参与有偿工作的情况在治疗多年后仍受影响，并突出了在童年allo-SCT后的康复过程中纳入职业援助的必要性。
