Lin Yan-Ping, Xu Cai-Lin, Lin Kui-Sheng, Gu Hai-Bin, Chen Lei, Wang Ying, Weng Bao-Chuan, Huang Hai-Qing, Li Ya-Ping, Zou Yu-Liang, Li Zi-Shun
Department of Clinical Laboratory, The Third Hospital of Xiamen, Xiamen, China.
Department of Gynaecology and Obstetrics, The Third Hospital of Xiamen, Xiamen, China.
J Obstet Gynaecol Res. 2018 Apr;44(4):655-662. doi: 10.1111/jog.13557. Epub 2018 Jan 5.
We aimed to explore the relation between the level of adipocyte fatty-acid binding protein (A-FABP) in the gestational period and related indices of glucolipid metabolism, and the possible mechanisms of occurrence and development of pre-eclampsia.
Seventy-six pre-eclampsia patients were enrolled and divided into the mild pre-eclampsia (n = 42) and severe pre-eclampsia (n = 34) groups. Forty-eight healthy pregnant women were selected as a control group. The indices of all participants were examined, including serum A-FABP, fasting insulin (FINS), fasting blood glucose, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), and homeostatic model assessment insulin resistance (HOMA-IR) index was calculated. After the delivery of the placenta, the level of A-FABP in the placenta was detected by immunochemistry. Then, the correlation between serum A-FABP and indices of glucolipid metabolism and placental A-FABP were analyzed.
Serum A-FABP, FINS, TG, TC, HOMA-IR, and placental A-FABP were significantly higher in pre-eclampsia patients and the level of HDL was obviously lower than in the control group. Serum A-FABP was positively correlated with FINS, TG, TC, and HOMA-IR, and placental A-FABP was negatively correlated with HDL in pre-eclampsia patients. In the control group, serum A-FABP was positively correlated only with TG, and uncorrelated with the other indices (P > 0.05).
The level of A-FABP was correlated with insulin resistance and indices of glucolipid metabolism in pre-eclampsia patients. High-levels of A-FABP might increase insulin resistance by causing glucose and lipid metabolism disorders and ultimately inducing the occurrence and development of pre-eclampsia.
探讨孕期脂肪细胞脂肪酸结合蛋白（A-FABP）水平与糖脂代谢相关指标的关系，以及子痫前期发生发展的可能机制。
纳入76例子痫前期患者，分为轻度子痫前期组（n = 42）和重度子痫前期组（n = 34）。选取48例健康孕妇作为对照组。检测所有参与者的指标，包括血清A-FABP、空腹胰岛素（FINS）、空腹血糖、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL），并计算稳态模型评估胰岛素抵抗（HOMA-IR）指数。胎盘娩出后，采用免疫化学法检测胎盘中A-FABP水平。然后，分析血清A-FABP与糖脂代谢指标及胎盘A-FABP之间的相关性。
子痫前期患者血清A-FABP、FINS、TG、TC、HOMA-IR及胎盘A-FABP水平显著高于对照组，HDL水平明显低于对照组。子痫前期患者血清A-FABP与FINS、TG、TC及HOMA-IR呈正相关，胎盘A-FABP与HDL呈负相关。在对照组中，血清A-FABP仅与TG呈正相关，与其他指标无相关性（P > 0.05）。
子痫前期患者A-FABP水平与胰岛素抵抗及糖脂代谢指标相关。高水平的A-FABP可能通过引起糖脂代谢紊乱增加胰岛素抵抗，最终诱发子痫前期的发生发展。
