在对苯环利定产生身体依赖性的过程中及戒断后，大鼠纹状体中[3H]司哌隆的结合情况。

[3H]Spiperone binding in the rat striatum during the development of physical dependence on phencyclidine and after withdrawal.

作者信息

Spain J W, Klingman G I, Hruska R E

出版信息

Neurosci Lett. 1985 Jul 4;58(1):67-72. doi: 10.1016/0304-3940(85)90330-1.

Abstract

Binding of [3H]spiperone to dopamine D2 receptors was measured in the striatum of male rats that were infused with phencyclidine (PCP, 45 mg/kg per day) or vehicle (saline) via an intrajugular cannula for 1, 3.5, or 7 days. The 7-day PCP infusion, which was shown previously to induce physical dependence, produced a significant 30% decrease in receptor density (Bmax). Two days after termination of the 7-day PCP infusion, Bmax values were no longer significantly lower than those of saline-infused controls. The acute administration of PCP (20 mg/kg, i.p.) did not alter receptor density 45 min later.

摘要

通过颈内插管，对雄性大鼠纹状体中[3H]司哌罗宁与多巴胺D2受体的结合进行了测定。这些大鼠连续1、3.5或7天经颈内插管注入苯环利定（PCP，每天45毫克/千克）或溶媒（生理盐水）。先前已证明，连续7天注入PCP可诱导身体依赖，该处理使受体密度（Bmax）显著降低了30%。在连续7天注入PCP结束后两天，Bmax值不再显著低于注入生理盐水的对照组。急性给予PCP（20毫克/千克，腹腔注射）45分钟后，受体密度未发生改变。