Department of Infectious Diseases, Center for Vaccines and Immunology, University of Georgia, College of Veterinary Medicine, Athens, GA 30602, USA.
Department of Infectious Diseases, Center for Vaccines and Immunology, University of Georgia, College of Veterinary Medicine, Athens, GA 30602, USA.
Curr Biol. 2018 Jan 8;28(1):R30-R33. doi: 10.1016/j.cub.2017.10.067.
Lipopolysaccharide synthesis and transport pathways are attractive targets for the development of new antimicrobial therapeutics. The ABC (ATP Binding Cassette) transporter MsbA has been recently described as employing a 'trap and flip' mechanism of lipopolysaccharide transport. This represents a novel mechanism amongst known lipid ABC transporters.
脂多糖的合成和转运途径是开发新型抗菌治疗方法的有吸引力的靶点。ABC（ATP 结合盒）转运蛋白 MsbA 最近被描述为采用“捕获和翻转”的脂多糖转运机制。这代表了已知脂质 ABC 转运蛋白中的一种新机制。
