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Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.胶质瘤内在基因表达亚型的肿瘤进化与微环境中的免疫变化相关。
Cancer Cell. 2018 Jan 8;33(1):152. doi: 10.1016/j.ccell.2017.12.012.
2
The intrinsic fusogenicity of glioma cells as a factor of transformation and progression in the tumor microenvironment.胶质瘤细胞的内在融合性作为肿瘤微环境中转化和进展的一个因素。
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Importance of immune monitoring approaches and the use of immune checkpoints for the treatment of diffuse intrinsic pontine glioma: From bench to clinic and vice versa (Review).免疫监测方法的重要性以及免疫检查点在弥漫性内生性桥脑胶质瘤治疗中的应用：从基础到临床及反之亦然（综述）。
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Identification of molecular pathways facilitating glioma cell invasion in situ.促进胶质瘤细胞原位侵袭的分子途径的鉴定
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Co-expression modules of NF1, PTEN and sprouty enable distinction of adult diffuse gliomas according to pathway activities of receptor tyrosine kinases.NF1、PTEN和Sprouty的共表达模块可根据受体酪氨酸激酶的信号通路活性区分成人弥漫性胶质瘤。
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Segregation of non-p.R132H mutations in IDH1 in distinct molecular subtypes of glioma.IDH1 中除非 p.R132H 突变的分离存在于不同的胶质瘤分子亚型中。
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Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model.在小鼠胶质瘤切除和复发模型中，反应性星形胶质细胞增强肿瘤侵袭性。
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Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake.联合 PET 成像炎症肿瘤微环境识别独特放射性示踪剂摄取的边界。
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Molecular subtypes of glioma identified by genome-wide methylation profiling.通过全基因组甲基化分析鉴定的脑胶质瘤分子亚型。
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引用本文的文献

1
Genomic landscape and immunological profile of glioblastoma in East Asian patients.东亚患者胶质母细胞瘤的基因组图谱和免疫特征
Cell Rep Med. 2025 Aug 19;6(8):102217. doi: 10.1016/j.xcrm.2025.102217.
2
Cellular heterogeneity and therapeutic response profiling of human IDH+ glioma stem cell cultures.人异柠檬酸脱氢酶（IDH）阳性胶质瘤干细胞培养物的细胞异质性和治疗反应分析
bioRxiv. 2025 Aug 1:2025.07.29.667532. doi: 10.1101/2025.07.29.667532.
3
The Circadian Rhythm Gene Network Could Distinguish Molecular Profile and Prognosis for Glioblastoma.昼夜节律基因网络可区分胶质母细胞瘤的分子特征和预后。
Int J Mol Sci. 2025 Jun 19;26(12):5873. doi: 10.3390/ijms26125873.
4
Multi-Transcriptomic Analysis Reveals GSC-Driven MES-Like Differentiation via EMT in GBM Cell-Cell Communication.多转录组分析揭示了胶质母细胞瘤细胞间通讯中通过上皮-间质转化由胶质瘤干细胞驱动的间充质样分化。
Biomedicines. 2025 May 26;13(6):1304. doi: 10.3390/biomedicines13061304.
5
Single-cell transcriptome sequencing reveals new epithelial-stromal associated mesenchymal-like subsets in recurrent gliomas.单细胞转录组测序揭示了复发性胶质瘤中新的上皮-间质相关间充质样亚群。
Acta Neuropathol Commun. 2025 Jun 7;13(1):127. doi: 10.1186/s40478-025-02036-6.
6
Machine learning and multi-omics analysis reveal key regulators of proneural-mesenchymal transition in glioblastoma.机器学习和多组学分析揭示胶质母细胞瘤中神经前体细胞-间充质转化的关键调节因子。
Sci Rep. 2025 Jun 5;15(1):19731. doi: 10.1038/s41598-025-04862-z.
7
Rapidly progressive scalp and lung metastases with fatal pneumothorax in glioblastoma, IDH-wildtype, with MET and CDK6 amplifications: a case report of clinical course and postmortem autopsy, including genetic analysis.胶质母细胞瘤（异柠檬酸脱氢酶野生型，伴有MET和CDK6扩增）出现快速进展的头皮和肺部转移并导致致命性气胸：临床病程及尸检报告，包括基因分析
Brain Tumor Pathol. 2025 May 20. doi: 10.1007/s10014-025-00503-5.
8
Novel metabolic subtypes in IDH-mutant gliomas: implications for prognosis and therapy.异柠檬酸脱氢酶（IDH）突变型胶质瘤中的新型代谢亚型：对预后和治疗的意义
BMC Cancer. 2025 Apr 30;25(1):815. doi: 10.1186/s12885-025-14176-y.
9
Synthetic lethality through Gsk3β inhibition in glioma stem cells via the WNT-WWC1-YAP axis.通过WNT-WWC1-YAP轴抑制胶质瘤干细胞中的Gsk3β实现合成致死性。
Oncogene. 2025 Apr 23. doi: 10.1038/s41388-025-03418-9.
10
Multi-transcriptomics reveals niche-specific expression programs and endothelial cells in glioblastoma.多转录组学揭示了胶质母细胞瘤中特定微环境的表达程序和内皮细胞。
J Transl Med. 2025 Apr 15;23(1):444. doi: 10.1186/s12967-025-06185-z.

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.

作者信息

Wang Qianghu, Hu Baoli, Hu Xin, Kim Hoon, Squatrito Massimo, Scarpace Lisa, deCarvalho Ana C, Lyu Sali, Li Pengping, Li Yan, Barthel Floris, Cho Hee Jin, Lin Yu-Hsi, Satani Nikunj, Martinez-Ledesma Emmanuel, Zheng Siyuan, Chang Edward, Gabriel Sauvé Charles-Etienne, Olar Adriana, Lan Zheng D, Finocchiaro Gaetano, Phillips Joanna J, Berger Mitchel S, Gabrusiewicz Konrad R, Wang Guocan, Eskilsson Eskil, Hu Jian, Mikkelsen Tom, DePinho Ronald A, Muller Florian, Heimberger Amy B, Sulman Erik P, Nam Do-Hyun, Verhaak Roel G W

出版信息

Cancer Cell. 2018 Jan 8;33(1):152. doi: 10.1016/j.ccell.2017.12.012.

DOI:10.1016/j.ccell.2017.12.012
PMID:29316430
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5892424/
Abstract
摘要