Piuzzi Nicolas S, Khlopas Anton, Sodhi Nipun, Oak Sameer, Sultan Assem A, Chughtai Morad, Mantripragada Venkata P, Mont Michael A, Muschler George F
Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio, Instituto Universitario del Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio.
Surg Technol Int. 2017 Dec 22;31:359-364.
The orthopedic field has experienced several major practice-changing pivotal shifts in the past several decades, such as the invention and application of the arthroscope or the implementation and advancement of joint arthroplasties. Most of these previous breakthroughs have focused on surgical techniques and devices. However, the next major advance in the field is likely to be related to biologic treatments. Although still in its early stage of development, orthopedic regenerative medicine, including cellular therapies, represents a great opportunity, since we are only beginning to understand their biological potential. The main challenge in this pathway is to translate the promising results obtained by basic scientists to clinical practice. This work reviewed the market and clinical evidence, as well as future perspectives, concerning cellular therapies in orthopedics.
在过去几十年里，骨科领域经历了几次重大的、改变实践的关键转变，比如关节镜的发明与应用，或者关节置换术的实施与发展。此前的这些重大突破大多集中在手术技术和器械方面。然而，该领域的下一个重大进展可能与生物治疗有关。尽管骨科再生医学仍处于发展初期，包括细胞疗法在内，但它代表了一个巨大的机遇，因为我们才刚刚开始了解它们的生物学潜力。这条道路上的主要挑战是将基础科学家取得的有前景的成果转化为临床实践。这项工作回顾了有关骨科细胞疗法的市场情况、临床证据以及未来前景。
