Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
General Dentist, Shoreview Dental, LLC, Keizer, 97303 OR, USA.
Int J Environ Res Public Health. 2018 Jan 6;15(1):80. doi: 10.3390/ijerph15010080.
Silver nitrate has been adopted for medical use as a disinfectant for eye disease and burned wounds. In dentistry, it is an active ingredient of Howe's solution used to prevent and arrest dental caries. While medical use of silver nitrate as a disinfectant became subsidiary with the discovery of antibiotics, its use in caries treatment also diminished with the use of fluoride in caries prevention. Since then, fluoride agents, particularly sodium fluoride, have gained popularity in caries prevention. However, caries is an infection caused by cariogenic bacteria, which demineralise enamel and dentine. Caries can progress and cause pulpal infection, but its progression can be halted through remineralisation. Sodium fluoride promotes remineralisation and silver nitrate has a profound antimicrobial effect. Hence, silver nitrate solution has been reintroduced for use with sodium fluoride varnish to arrest caries as a medical model strategy of caries management. Although the treatment permanently stains caries lesions black, this treatment protocol is simple, painless, non-invasive, and low-cost. It is well accepted by many clinicians and patients and therefore appears to be a promising strategy for caries control, particularly for young children, the elderly, and patients with severe caries risk or special needs.
硝酸银已被采用作为一种消毒剂,用于眼部疾病和烧伤伤口的治疗。在牙科领域,它是豪氏溶液的一种有效成分,用于预防和控制龋齿。虽然随着抗生素的发现,硝酸银作为消毒剂的医学用途已退居次要地位,但随着氟化物在龋齿预防中的应用,其在龋齿治疗中的应用也有所减少。从那时起,氟化物制剂,特别是氟化钠,在龋齿预防中变得越来越受欢迎。然而,龋齿是由致龋细菌引起的感染,会使牙釉质和牙本质脱矿。龋齿可以进展并导致牙髓感染,但通过再矿化可以阻止其进展。氟化钠促进再矿化,而硝酸银具有深远的抗菌作用。因此,硝酸银溶液已重新与氟化钠涂料一起用于龋齿的治疗,作为龋齿管理的医学模型策略。尽管这种治疗会使龋齿病变永久性地染成黑色,但这种治疗方案简单、无痛、无创且成本低廉。它已被许多临床医生和患者广泛接受,因此似乎是一种很有前途的龋齿控制策略,特别是对于儿童、老年人以及有严重龋齿风险或特殊需求的患者。