Zheng Wei, Huang Wenyu, Zhang Li, Tian Zhihong, Wang Teng, Zhang Ting, Zhang Zhi, Zhang Weiyuan, Li Guanghui
1 Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Chaoyang District, Beijing, China.
2 Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Reprod Sci. 2018 Sep;25(9):1406-1412. doi: 10.1177/1933719117746785. Epub 2018 Jan 9.
This study is aimed to characterize changes in serum lipid levels throughout pregnancy and explore the association between lipid levels and neonatal outcomes.
This study included singleton pregnancy women who received regular prenatal care and delivered at Beijing Obstetrics and Gynecology Hospital from January 2014 to December 2014. Baseline information and neonatal outcomes were collected from medical record review. Serum lipid levels in the first trimester (7-13 weeks) and third trimester (>32 weeks) were measured. A multivariate regression model was constructed to examine the association between lipid levels and neonatal outcomes. Covariance structure analysis was conducted to explore the contribution of lipid profiles on birth weight.
A total of 10 366 pregnant women were included in the analysis. Triglyceride (TG) and total cholesterol levels increased significantly from the first trimester to the third trimester. Triglyceride levels in both early and late pregnancy were significantly associated with an increased risk of macrosomia and preterm birth. Serum lipid levels in the first trimester significantly contributed to the lipid levels in the third trimester, while TG and high-density lipoprotein cholesterol in the third trimester were associated with birth weight.
Elevated TG levels throughout pregnancy were associated with an increased risk of preterm delivery and macrosomia. Serum lipid levels in the third trimester are mainly accounted for by their levels in the first trimester and are also associated with birth weight.
本研究旨在描述整个孕期血清脂质水平的变化，并探讨脂质水平与新生儿结局之间的关联。
本研究纳入了2014年1月至2014年12月在北京妇产医院接受常规产前检查并分娩的单胎妊娠妇女。通过病历回顾收集基线信息和新生儿结局。测量孕早期（7 - 13周）和孕晚期（>32周）的血清脂质水平。构建多变量回归模型以检验脂质水平与新生儿结局之间的关联。进行协方差结构分析以探讨脂质谱对出生体重的影响。
共有10366名孕妇纳入分析。甘油三酯（TG）和总胆固醇水平从孕早期到孕晚期显著升高。孕早期和孕晚期的甘油三酯水平均与巨大儿和早产风险增加显著相关。孕早期的血清脂质水平对孕晚期的脂质水平有显著影响，而孕晚期的TG和高密度脂蛋白胆固醇与出生体重相关。
整个孕期TG水平升高与早产和巨大儿风险增加相关。孕晚期的血清脂质水平主要由孕早期的水平决定，并且也与出生体重相关。
