2,3,7,8-四氯二苯并对二恶英诱导心血管毒性的机制：综述
Mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced cardiovascular toxicity: An overview.
作者信息
Mohsenzadeh Mahdieh Sadat, Zanjani Bamdad Riahi, Karimi Gholamreza
机构信息
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, P.O. Box, 91375-345, Iran.
Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, P.O. Box, 91375-345, Iran.
出版信息
Chem Biol Interact. 2018 Feb 25;282:1-6. doi: 10.1016/j.cbi.2018.01.002. Epub 2018 Jan 6.
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant and its toxicity is mediated by the aryl hydrocarbon receptor (AHR). Mechanisms of TCDD cardiovascular toxicity consist of oxidative stress, growth factor modulation, and ionic current alteration. It is indicated that the rodent cardiovascular system is a target for TCDD cardiomyopathy. Here, our understanding of TCDD cardiovascular toxicity is reviewed.
2,3,7,8-四氯二苯并对二恶英（TCDD）是一种环境污染物，其毒性由芳烃受体（AHR）介导。TCDD心血管毒性的机制包括氧化应激、生长因子调节和离子电流改变。有研究表明啮齿动物的心血管系统是TCDD诱导心肌病的靶器官。在此，我们对TCDD心血管毒性的认识进行综述。
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