四氧嘧啶诱导的糖尿病大鼠的肾上腺皮质功能。
The adrenocortical function of alloxan-induced diabetic rats.
作者信息
Lin J H, Shieh M H, Wu L S, Lin W H
出版信息
Proc Natl Sci Counc Repub China B. 1985 Apr;9(2):97-102.
The purpose of this study is to investigate the adrenocortical function of alloxan-induced diabetic rats. Male rats of Wistar strain, weighing 200-250 gm were used. The results indicated that the adrenocortical response to stress and exogenous corticotropin (ACTH1-24) is decreased during the early diabetic stages (up to 6 days). Evidence from in vivo and in vitro studies shows that the depression is caused by the toxicity of alloxan on the adrenal cortex cells and not by the sudden rise of blood glucose levels. Streptozotocin (another diabetogen) has the same effect as alloxan on adrenal cortex cells.
本研究的目的是调查四氧嘧啶诱导的糖尿病大鼠的肾上腺皮质功能。使用体重为200 - 250克的雄性Wistar品系大鼠。结果表明，在糖尿病早期阶段（长达6天），肾上腺皮质对应激和外源性促肾上腺皮质激素（ACTH1 - 24）的反应降低。体内和体外研究的证据表明，这种抑制是由四氧嘧啶对肾上腺皮质细胞的毒性引起的，而不是由血糖水平的突然升高引起的。链脲佐菌素（另一种致糖尿病剂）对肾上腺皮质细胞的作用与四氧嘧啶相同。
Zotero 插件