School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.
Department of Medical Genetics, Medical University of Silesia, Jedności 8 Street, 41-200 Sosnowiec, Poland.
Mediators Inflamm. 2017;2017:6016023. doi: 10.1155/2017/6016023. Epub 2017 Nov 29.
Schizophrenia is a devastating mental disorder with undetermined aetiology. Previous research has suggested that dysregulation of proinflammatory cytokines and their receptors plays a role in developing schizophrenia. We examined the association of the three single nucleotide polymorphisms (SNPs; rs4149576, rs4149577, and rs1860545) in the tumor necrosis factor receptor 1 gene with the development and psychopathology of paranoid schizophrenia in the Polish Caucasian sample consisting of 388 patients and 657 control subjects. The psychopathology was assessed using a five-factor model of the Positive and Negative Syndrome Scale (PANSS). SNPs were genotyped using the TaqMan 5'-exonuclease allelic discrimination assay. The SNPs tested were not associated with a predisposition to paranoid schizophrenia in either the entire sample or after stratification according to gender. However, rs4149577 and rs1860545 SNPs were associated with the intensity of the PANSS excitement symptoms in men, which may contribute to the risk of violent behavior. Polymorphisms in the gene may have an impact on the symptomatology of schizophrenia in men.
精神分裂症是一种病因不明的严重精神障碍。先前的研究表明，促炎细胞因子及其受体的失调在精神分裂症的发展中起作用。我们研究了肿瘤坏死因子受体 1 基因中的三个单核苷酸多态性（SNP；rs4149576、rs4149577 和 rs1860545）与波兰白种人样本中偏执型精神分裂症的发病机制和精神病理学之间的关联，该样本包括 388 名患者和 657 名对照。使用阳性和阴性症状量表（PANSS）的五因素模型评估精神病理学。使用 TaqMan 5'-exonuclease 等位基因鉴别检测法对 SNP 进行基因分型。在整个样本或根据性别分层后，测试的 SNP 均与偏执型精神分裂症的易感性无关。然而，rs4149577 和 rs1860545 SNP 与男性 PANSS 兴奋症状的强度相关，这可能导致暴力行为的风险增加。基因中的多态性可能对男性精神分裂症的症状学有影响。
