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Lack of Benefit With Idalopirdine for Alzheimer Disease: Another Therapeutic Failure in a Complex Disease Process.

作者信息

Bennett David A

机构信息

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Ilinois.

出版信息

JAMA. 2018 Jan 9;319(2):123-125. doi: 10.1001/jama.2017.19700.

DOI:10.1001/jama.2017.19700
PMID:29318261
Abstract
摘要

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Lack of Benefit With Idalopirdine for Alzheimer Disease: Another Therapeutic Failure in a Complex Disease Process.茚达品治疗阿尔茨海默病无效:复杂疾病进程中的又一治疗失败案例
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Effects of the 5-HT receptor antagonist idalopirdine on extracellular levels of monoamines, glutamate and acetylcholine in the rat medial prefrontal cortex.5-羟色胺受体拮抗剂依达拉奉对大鼠内侧前额叶皮质中单胺、谷氨酸和乙酰胆碱细胞外水平的影响。
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The 5-HT6 receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus.5-羟色胺6受体拮抗剂伊达比星可增强乙酰胆碱酯酶抑制对大鼠背侧海马体神经网络振荡和细胞外乙酰胆碱水平的影响。
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