Cellular and Systems Neurobiology, Systems Biology Program, The Barcelona Institute of Science and Technology, Centre for Genomic Regulation (CRG), Spain.
Comparative Bioinformatics, Bioinformatics and Genomics Program, Barcelona Institute of Science and Technology, Centre for Genomic Regulation (CRG), Spain.
Addict Biol. 2018 Mar;23(2):531-543. doi: 10.1111/adb.12595. Epub 2018 Jan 10.
Obesity represents an important risk factor contributing to the global burden of disease. The current obesogenic environment with easy access to calorie-dense foods is fueling this obesity epidemic. However, how these foods contribute to the progression of feeding behavior changes that lead to overeating is not well understood and needs systematic assessment. Using novel automated methods for the high-throughput screening of behavior, we here examine mice meal pattern upon long-term exposure to a free-choice chocolate-mixture diet and a high-fat diet with face validity for a rapid development of obesity induced by unhealthy food regularly consumed in our societies. We identified rapid diet-specific behavioral changes after exposure to those high-caloric diets. Mice fed with high-fat chow, showed long-lasting meal pattern disturbances, which initiate with a stable loss of circadian feeding rhythmicity. Mice receiving a chocolate-mixture showed qualitatively similar changes, though less marked, consisting in a transient disruption of the feeding behavior and the circadian feeding rhytmicity. Strikingly, compulsive-like eating behavior is triggered immediately after exposure to both high-fat food and chocolate-mixture diet, well before any changes in body weight could be observed. We propose these changes as behavioral biomarkers of prodromal states of obesity that could allow early intervention.
肥胖是导致全球疾病负担的一个重要危险因素。当前这种容易获得高热量食物的致肥胖环境正在推动肥胖的流行。然而，这些食物如何导致导致暴饮暴食的进食行为变化的进展还不太清楚，需要进行系统评估。我们使用新颖的自动化方法进行高通量行为筛选，在此检查了长期暴露于自由选择巧克力混合物饮食和高脂肪饮食后，老鼠的进食模式，这些饮食具有快速发展肥胖的表面有效性，这是由我们社会中经常食用的不健康食物引起的。在暴露于这些高热量饮食后，我们发现了特定于饮食的快速行为变化。用高脂肪饲料喂养的老鼠表现出持久的进食模式紊乱，其起始于稳定的昼夜节律性摄食节律丧失。接受巧克力混合物的老鼠表现出类似但不太明显的变化，表现为进食行为和昼夜节律性摄食节律的短暂中断。引人注目的是，强迫性进食行为在接触高脂肪食物和巧克力混合物饮食后立即被触发，远早于观察到体重变化之前。我们提出这些变化作为肥胖前状态的行为生物标志物，可用于早期干预。
