比较三种预测胃肠道间质瘤患者癌症特异性生存的预后模型。
Comparison of three prognostic models for predicting cancer-specific survival among patients with gastrointestinal stromal tumors.
机构信息
Oncology Department, Swiss Cancer Institute, Cham, Switzerland.
Department of General, Visceral & Transplant Surgery, University of Heidelberg, Heidelberg, Germany.
出版信息
Future Oncol. 2018 Feb;14(4):379-389. doi: 10.2217/fon-2017-0450. Epub 2018 Jan 10.
AIM
To evaluate the predictive value for cancer-specific survival of the models of the American Joint Committee on Cancer (AJCC) stage, NIH and Armed Forces Institute of Pathology (AFIP) among patients with gastrointestinal stromal tumors (GISTs).
METHODS
Surveillance, Epidemiology and End Results database (2010-2014) was accessed. Overall survival analysis and adjusted cancer-specific Cox regression hazard was calculated.
RESULTS
For gastric GISTs, concordance-index according to AJCC was 0.834; according to NIH was 0.833; according to AFIP was 0.836. Concordance-index for nongastric GISTs according to AJCC was 0.800, according to NIH was 0.801 and according to AFIP was 0.799.
CONCLUSION
The performance of the three models is comparable with regards to cancer-specific survival prediction.
目的
评估美国癌症联合委员会（AJCC）分期、NIH 和武装部队病理研究所（AFIP）模型对胃肠道间质瘤（GIST）患者癌症特异性生存的预测价值。
方法
检索监测、流行病学和最终结果数据库（2010-2014 年）。进行总生存分析和调整后的癌症特异性 Cox 回归风险计算。
结果
对于胃 GIST，根据 AJCC 的一致性指数为 0.834；根据 NIH 的一致性指数为 0.833；根据 AFIP 的一致性指数为 0.836。根据 AJCC 的非胃 GIST 的一致性指数为 0.800，根据 NIH 的一致性指数为 0.801，根据 AFIP 的一致性指数为 0.799。
结论
在预测癌症特异性生存方面，这三个模型的性能相当。
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