Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
Curr Pharm Des. 2018;24(7):754-771. doi: 10.2174/1381612824666180110103348.
There is an increased need to find non-invasive tools for early diagnosis and follow-up of infections. Nuclear medicine techniques may be used to diagnose, localize and evaluate the severity and the extent of infections before the occurrence of anatomical abnormalities. This review focuses on different approaches based on radiolabelled cells, peptides and antibodies or [18F]FDG to image infective diseases in agreement with what is being jointly evaluated by the European Association of Nuclear Medicine (EANM). This is particularly relevant, since the EANM has strated a wide program of collaboration with other European clinical societies to define common diagnostic flow-charts in many of these infective diseases. It emerges the role of radiolabelled WBC by SPECT/CT for prosthetic joint infections and of FDG by PET/CT for spondylodiscitis. Comparable values of accuracy have been described for WBC and FDG in the diagnosis of vascular fgraft infections, diabetic gfoot, endocarditis and peripheral bone osteomyelitis, with some exceptions.
人们越来越需要寻找非侵入性工具来进行早期诊断和随访感染。核医学技术可用于在发生解剖异常之前诊断、定位和评估感染的严重程度和范围。这篇综述重点介绍了基于放射性标记细胞、肽和抗体或 [18F]FDG 的不同方法，以根据欧洲核医学协会 (EANM) 的联合评估来成像感染性疾病。这一点尤为重要，因为 EANM 已经与其他欧洲临床学会开展了广泛的合作计划，以在许多感染性疾病中定义共同的诊断流程。这凸显了 SPECT/CT 中放射性标记白细胞 (WBC) 在人工关节感染和 PET/CT 中 18F-FDG 在脊柱骨髓炎中的作用。在诊断血管移植物感染、糖尿病足、心内膜炎和外周骨骨髓炎方面，WBC 和 FDG 的准确性描述值相当，但也存在一些例外。
