冠状动脉疾病预防与管理中的遗传学
Genetics in the prevention and management of coronary artery disease.
作者信息
Roberts Robert
机构信息
Department of Medicine for University of Arizona College of Medicine-Phoenix.
International Society of Cardiovascular Translational Research (ISCTR), Phoenix, Arizona, USA.
出版信息
Curr Opin Cardiol. 2018 May;33(3):257-268. doi: 10.1097/HCO.0000000000000501.
PURPOSE OF REVIEW
The current review is to describe the genetic risk variants that have been discovered predisposing to coronary artery disease (CAD) and how they are utilized to stratify for risk of CAD.
RECENT FINDINGS
Over 90 genetic risk variants have been discovered that predispose to risk for CAD.
SUMMARY
The total genetic risk burden for CAD is proportional to the number of risk variants inherited and can be combined into a single number referred to as the genetic risk score (GRS). GRS has been utilized in multiple studies and shown to be more effective in risk stratification for CAD than conventional risk factors. There is a major advantage to risk stratification based on the GRS since the risk can be determined at birth or anytime throughout one's lifetime since the individual's DNA does not change. Widespread application of the GRS is likely to enable a paradigm shift in the primary prevention of CAD.
综述目的
本综述旨在描述已发现的易患冠状动脉疾病（CAD）的遗传风险变异，以及它们如何用于CAD风险分层。
最新发现
已发现90多个易患CAD风险的遗传风险变异。
总结
CAD的总遗传风险负担与遗传的风险变异数量成正比，可合并为一个称为遗传风险评分（GRS）的单一数字。GRS已在多项研究中得到应用，并且在CAD风险分层方面比传统风险因素更有效。基于GRS进行风险分层有一个主要优势，即由于个体的DNA不会改变，因此可以在出生时或一生中的任何时候确定风险。GRS的广泛应用可能会使CAD一级预防的模式发生转变。
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