Ferreira Simone Alves Dos Santos, Moraes Ana Cristina de, Terzi Renato Giuseppe Giovanni, Ferreira Evandro Luis Assis, Silva William Adalberto, Moreira Marcos Mello
Fellow Master degree, Postgraduate Program in Sciences of Surgery, Faculty of Medical School, Universidade Estadual de Campinas (UNICAMP), Brazil. Manuscript preparation.
Biologist, Center for Experimental Medicine and Surgery, Faculty of Medical Sciences, UNICAMP, Campinas-SP, Brazil. Design the protocol, technical procedures, acquisition and interpretation of data, manuscript writing.
Acta Cir Bras. 2017 Dec;32(12):1036-1044. doi: 10.1590/s0102-865020170120000005.
To use blood lactate (BL) as an end-point metabolic marker for the begin resuscitation of volume replacement in experimental hemorrhagic shock.
Group I (n=7) was not bled (Control). Animals in Group II (n=7) were bled to a MAP of 30mmHg in thirty minutes. Hemodynamic and metabolic data were recorded at Baseline, at 30, 60 and 120 minutes after Baseline. The animals were intubated in spontaneous breathing (FIO2=0.21) with halothane.
Group I all survived. In Group II all died; no mortality occurred before a BL<10mM/L. Beyond the end-point all animals exhibited severe acidemia, hyperventilation and clinical signs of shock. Without treatment all animals died within 70.43±24.51 min of hypotension shortly after reaching an average level of BL 17.01±3.20mM/L.
Swine's breathing room air spontaneously in hemorrhagic shock not treated a blood lactate over 10mM/L results fatal. The predictable outcome of this shock model is expected to produce consistent information based on possible different metabolic and hemodynamic patterns as far as the type of fluid and the timing of resuscitation in near fatal hemorrhagic shock.
将血乳酸（BL）作为实验性失血性休克中开始容量复苏的终点代谢标志物。
第一组（n = 7）不进行放血（对照组）。第二组（n = 7）的动物在30分钟内放血至平均动脉压（MAP）为30mmHg。在基线、基线后30、60和120分钟记录血流动力学和代谢数据。动物在自主呼吸（吸入氧分数FIO2 = 0.21）下用氟烷进行插管。
第一组全部存活。第二组全部死亡；在血乳酸<10mM/L之前未发生死亡。超过终点后，所有动物均出现严重酸血症、通气过度和休克的临床体征。未经治疗，所有动物在平均血乳酸水平达到17.01±3.20mM/L后不久，在低血压70.43±24.51分钟内死亡。
失血性休克中猪自主呼吸室内空气时，血乳酸超过10mM/L且未治疗会导致死亡。对于近乎致命的失血性休克，基于可能不同的代谢和血流动力学模式，就液体类型和复苏时机而言，该休克模型可预测的结果有望产生一致的信息。
