Kobayashi S, Nagase M, Kimura M, Ohyama K, Ikeya M, Honda N
Am J Nephrol. 1985;5(4):282-9. doi: 10.1159/000166947.
5 cases with the compatible serological criteria of mixed connective tissue disease described earlier are presented. In 1 of them with a moderate degree of proteinuria, the renal biopsy disclosed membranous nephritis. However, despite the absence of overt clinical renal disease in the other 4 cases, biopsies disclosed membranous nephritis in 1 and mild mesangial proliferative glomerulonephritis in the remaining 3 cases. In the follow-up of these 4 cases, 2 subsequently developed abnormal urinalysis. Electron microscopic examinations demonstrated electron-dense deposits in glomeruli, and 4 of these patients also had microtubular structures in the endothelial cytoplasm. Contrarily to the original concept, our findings suggest that mixed connective tissue disease also induces immune complex disease.
本文报告了5例符合先前所述混合性结缔组织病血清学标准的病例。其中1例有中度蛋白尿，肾活检显示为膜性肾炎。然而，尽管其他4例没有明显的临床肾脏疾病，但活检显示其中1例为膜性肾炎，其余3例为轻度系膜增生性肾小球肾炎。在对这4例病例的随访中，有2例随后出现尿液分析异常。电子显微镜检查显示肾小球中有电子致密沉积物，其中4例患者在内皮细胞质中也有微管结构。与最初的概念相反，我们的研究结果表明混合性结缔组织病也可诱发免疫复合物疾病。
