Department of Urology, VU university Medical Center, Amsterdam, The Netherlands.
Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.
BJU Int. 2018 Oct;122(4):571-575. doi: 10.1111/bju.14124. Epub 2018 Jan 31.
To investigate whether the timing of an immediate instillation of mitomycin C (on the day of transurethral resection of bladder tumour [TURBT] or 1 day later) has an impact on time to recurrence of non-muscle-invasive bladder cancer (NMIBC).
All patients with NMIBC who were enrolled in a prospective trial between 1998 and 2003, and treated with an early mitomycin C instillation (on the day of TURBT or 1 day later), were selected. Statistical analysis was performed with Kaplan-Meier curves and multivariable Cox regression.
Administering an instillation of mitomycin C on the day of TURBT or 1 day later did not show a statistically significant difference in time to recurrence in a univariable model (log-rank P = 0.99). After correcting for the number of scheduled adjuvant instillations, no statistically significant difference could be detected either: hazard ratio 1.05 (95% confidence interval 0.81-1.35, P = 0.74).
These data do not support the hypothesis that a very early instillation (on the day of TURBT) of mitomycin C decreases the risk of recurrence as compared with an early instillation (1 day after TURBT).
研究即刻给予丝裂霉素 C 灌注（在经尿道膀胱肿瘤切除术 [TURBT] 当天或第 1 天）的时机是否会影响非肌层浸润性膀胱癌（NMIBC）的复发时间。
选择了 1998 年至 2003 年期间参加前瞻性试验并接受早期丝裂霉素 C 灌注（在 TURBT 当天或第 1 天）治疗的所有 NMIBC 患者。采用 Kaplan-Meier 曲线和多变量 Cox 回归进行统计分析。
在单变量模型中，在 TURBT 当天或第 1 天给予丝裂霉素 C 灌注在复发时间上没有统计学显著差异（对数秩 P = 0.99）。在对计划辅助灌注次数进行校正后，也未发现统计学显著差异：风险比 1.05（95%置信区间 0.81-1.35，P = 0.74）。
这些数据不支持即刻（TURBT 当天）给予丝裂霉素 C 灌注比早期（TURBT 后第 1 天）灌注可降低复发风险的假设。
