回顾性检查猫白血病亚群特征：病毒干扰测定到深度测序。
A Retrospective Examination of Feline Leukemia Subgroup Characterization: Viral Interference Assays to Deep Sequencing.
机构信息
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80524, USA.
出版信息
Viruses. 2018 Jan 10;10(1):29. doi: 10.3390/v10010029.
Feline leukemia virus (FeLV) was the first feline retrovirus discovered, and is associated with multiple fatal disease syndromes in cats, including lymphoma. The original research conducted on FeLV employed classical virological techniques. As methods have evolved to allow FeLV genetic characterization, investigators have continued to unravel the molecular pathology associated with this fascinating agent. In this review, we discuss how FeLV classification, transmission, and disease-inducing potential have been defined sequentially by viral interference assays, Sanger sequencing, PCR, and next-generation sequencing. In particular, we highlight the influences of endogenous FeLV and host genetics that represent FeLV research opportunities on the near horizon.
猫白血病病毒（FeLV）是第一种发现的猫逆转录病毒，与猫的多种致命疾病综合征相关，包括淋巴瘤。最初对 FeLV 的研究采用了经典的病毒学技术。随着方法的发展，使得 FeLV 的基因特征得以确定，研究人员继续揭示与这种迷人的病原体相关的分子病理学。在这篇综述中，我们讨论了 FeLV 的分类、传播和致病潜力如何通过病毒干扰试验、Sanger 测序、PCR 和下一代测序依次得到定义。特别是，我们强调了内源性 FeLV 和宿主遗传因素的影响，这些因素代表了 FeLV 研究的机会，即将出现。
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