Mills S D, Azizoddin D, Gholizadeh S, Racaza G Z, Nicassio P M
1 464916 San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology , San Diego, CA, USA.
2 Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, USA.
Lupus. 2018 Jun;27(7):1185-1189. doi: 10.1177/0961203317751046. Epub 2018 Jan 10.
Objective Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can result in disability and psychological distress. Although pain has been associated with depressive symptomatology and stress in SLE, a paucity of theoretical models have been used to explain the relationship between pain and psychological distress in this population. Thus, the present study examined helplessness as a mediator of the relationship between pain and psychological distress among patients with SLE. Methods Multiple mediation analysis was used to examine the hypothesis that learned helplessness mediates the relationship between pain and symptoms of anxiety, depression, and stress in a sample of patients with SLE ( N = 136) receiving medical care at Cedars Sinai Medical Center. Results The mean score on the Helplessness subscale was 14.5 ( SD = 5.4). Helplessness fully mediated the relationship between pain vitality and symptoms of anxiety (BCa 95% CI (-0.073, -0.015)), depression (BCa 95% CI (-0.502, -0.212)), and stress (BCa 95% CI (-0.063, -0.027)). Conclusion Participants reported a high level of perceived inability to control one's disease. Helplessness fully mediated the relationship between pain and measures of anxiety, depression, and perceived stress among patients with SLE.
系统性红斑狼疮（SLE）是一种慢性自身免疫性疾病，可导致残疾和心理困扰。虽然疼痛与SLE患者的抑郁症状和压力有关，但很少有理论模型用于解释该人群中疼痛与心理困扰之间的关系。因此，本研究检验了无助感作为SLE患者疼痛与心理困扰之间关系的中介因素。方法：采用多重中介分析，检验习得性无助在西达赛奈医疗中心接受治疗的SLE患者样本（N = 136）中疼痛与焦虑、抑郁和压力症状之间关系的中介作用这一假设。结果：无助感分量表的平均得分为14.5（标准差 = 5.4）。无助感完全中介了疼痛活力与焦虑症状（BCa 95%置信区间（-0.073，-0.015））、抑郁症状（BCa 95%置信区间（-0.502，-0.212））和压力症状（BCa 95%置信区间（-0.063，-0.027））之间的关系。结论：参与者报告了较高的对疾病控制能力的感知不足。无助感完全中介了SLE患者疼痛与焦虑、抑郁和感知压力测量指标之间的关系。
