Nagpal J P, Khanduja K L, Sharma R R, Majumdar S, Singh R, Gupta M P, Dogra S C
Biochem Med. 1985 Aug;34(1):11-6. doi: 10.1016/0006-2944(85)90056-0.
Effect of depot medroxyprogesterone acetate on the hepatic drug-metabolizing enzymes was studied in female protein-deficient and normal pair-fed rats. Treatment with this drug did not cause any change in organ weight, microsomal protein, and soluble protein yield per gram of tissue in both groups. MPA administration resulted in significant increases in the content of cytochrome P-450 and b5, and activities of benzo[a]pyrene hydroxylase, UDP-glucuronosyltransferase, and NADPH-Cyt c reductase in both pair-fed control and protein-deficient rats. However, the content of glutathione and activity of glutathione-S-transferase were not affected appreciably. The present study suggests that MPA treatment induces drug-metabolizing enzymes in liver to almost the same extent in both protein-deficient and normal pair-fed rats.
在蛋白质缺乏的雌性大鼠和正常配对喂养的雌性大鼠中，研究了醋酸甲羟孕酮长效注射剂对肝脏药物代谢酶的影响。两组大鼠使用该药物治疗后，器官重量、微粒体蛋白以及每克组织的可溶性蛋白产量均未发生任何变化。在配对喂养的对照大鼠和蛋白质缺乏的大鼠中，给予醋酸甲羟孕酮均导致细胞色素P - 450和b5含量显著增加，以及苯并[a]芘羟化酶、尿苷二磷酸葡萄糖醛酸基转移酶和NADPH - 细胞色素c还原酶活性显著增加。然而，谷胱甘肽含量和谷胱甘肽 - S - 转移酶活性未受到明显影响。本研究表明，在蛋白质缺乏的大鼠和正常配对喂养的大鼠中，醋酸甲羟孕酮治疗对肝脏药物代谢酶的诱导程度几乎相同。
