Bhagde Priya Anil, Bhavthankar Jyoti D, Mandale Mandakini
Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Aurangabad, Maharashtra, India.
Indian J Pathol Microbiol. 2017 Oct-Dec;60(4):556-559. doi: 10.4103/IJPM.IJPM_401_17.
Granulomatosis is any condition characterized by the formation of multiple nodules or granulomas in the soft tissues. Differential diagnosis for orofacial region includes a wide spectrum of diseases, but most of these lesions present histopathologically as noncaseating granulomas, giving a nonspecific depiction and leading to a diagnostic impasse. In the absence of any diagnosable entity, the disease is labelled as "orofacial granulomatosis". A nine-year-old girl child reported with recurrent gingival enlargement and persistent macrochelia which histopathologically presented as noncaseating granulomas. The disease was progressive raising the suspicion of being oral manifestation of a systemic disorder such as Sarcoidosis or Crohn's disease. This paper throws some light on this rare entity and reports rarer features of this disease, like eye involvement and staphylococcal mucositis in the case report.
肉芽肿病是指任何以软组织中形成多个结节或肉芽肿为特征的病症。口面部区域的鉴别诊断包括多种疾病，但这些病变大多数在组织病理学上表现为非干酪样肉芽肿，呈现非特异性表现并导致诊断陷入僵局。在没有任何可诊断实体的情况下，该疾病被标记为“口面部肉芽肿病”。一名9岁女童报告有复发性牙龈肿大和持续性巨唇，组织病理学表现为非干酪样肉芽肿。该疾病呈进行性发展，引发了对其为全身性疾病如结节病或克罗恩病的口腔表现的怀疑。本文对这一罕见实体进行了一些阐述，并在病例报告中报告了该疾病更罕见的特征，如眼部受累和葡萄球菌性粘膜炎。
